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Cat. No.: HY-183623

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ProAlk01

ProAlk01 is a protein alkylating agent that serves as a toxin payload for ADCs. ProAlk01 localizes to the cytoplasm and exerts cytotoxic effects mainly by alkylating cytoplasmic proteins rather than binding to DNA. ProAlk01 induces cell cycle arrest, apoptosis, and immunogenic cell death. ProAlk01 can be used in the research of solid tumors.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 1296670-84-2
화학식: C₃₁H₂₈Cl₂N₂O₄
분자량:563.47

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

ProAlk01 Chemical Structure

CAS No.: 1296670-84-2

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One-stop CDMO Service

One-Stop Platform：From Independent R&D to Pilot-Scale Production

Biological Activity
- 제품 설명
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All ADC Payloads Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	2.7 nM Compound: BDA 2	Cytotoxicity against human A549 cells assessed as reduction in cell viability after 24 hrs by MTT assay Cytotoxicity against human A549 cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 30620194]

In Vitro

ProAlk01 (1-100 pM) exhibits potent in vitro cytotoxic activity across a broad panel of solid tumor cell lines with IC₅₀ values in the 1-100 pM range^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1296670-84-2
분자량 563.47
화학식 C₃₁H₂₈Cl₂N₂O₄
SMILES

O=C(N1C[C@H](C2=C1C=C(C3=C2C=CC=C3)O)CCl)CCCC(N4C[C@H](C5=C4C=C(C6=C5C=CC=C6)O)CCl)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Turska A, et al. PA289: A first-in-class prodrug payload with a novel mechanism of action and favorable efficacy/safety profile. Cancer Research. 2026 Apr 3;86(7_Supplement):1712-.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References

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ProAlk01

All ADC Payloads Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

ProAlk01 Related Classifications

HY-183623 Related Classifications