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United States

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Cat. No.: HY-12732

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PTC 725

PTC 725 is a potent, selective and orally active Hepatitis C Virus NS4B Protein inhibitor. PTC 725 inhibits HCV 1b (Con1) replicons.

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CAS No.: 1248581-07-8
화학식: C₂₃H₁₈F₄N₆O₂S
분자량:518.49

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

PTC 725 Chemical Structure

CAS No.: 1248581-07-8

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

PTC 725 is a potent, selective and orally active Hepatitis C Virus NS4B Protein inhibitor. PTC 725 inhibits HCV 1b (Con1) replicons^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
Huh-7	EC₅₀	2 nM Compound: 4t, PTC725	Antiviral activity against HCV1b Con1 infected in human HuH7 cells assessed as inhibition of viral RNA replication by RT-PCR analysis Antiviral activity against HCV1b Con1 infected in human HuH7 cells assessed as inhibition of viral RNA replication by RT-PCR analysis	[PMID: 24266880]
Huh-7	IC₅₀	>10000 nM Compound: 4t, PTC725	Toxicity in human HuH7 cells assessed as effect on GAPDH mRNA level Toxicity in human HuH7 cells assessed as effect on GAPDH mRNA level	[PMID: 24266880]

In Vitro

PTC 725 (0-1 µM; 3 days) inhibits HCV 1b (Con1) replicons with an EC₅₀ value of 1.7 nM and an EC₉₀ value of 9.6 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1248581-07-8
분자량 518.49
화학식 C₂₃H₁₈F₄N₆O₂S
SMILES

O=S(C1=CC=C(C(N2C3=NC=CC=N3)=C(C#N)C4=C2C=C(CC)C(F)=C4)N=C1)(N[C@@H](C)C(F)(F)F)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Gu Z, et al. Identification of PTC725, an orally bioavailable small molecule that selectively targets the hepatitis C Virus NS4B protein. Antimicrob Agents Chemother. 2013 Jul;57(7):3250-61. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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