S 1360
S 1360 is a potent and selective inhibitor of HIV-1 integrase. S 1360 inhibits the catalytic activity of purified integrase ( IC50: 20 nM). The EC50, and CC50 of S 1360 in MTT assay (MT-4 cells infected with HIV-1 IIIB) are 200 nM and 12 μM, respectively. S 1360 has antiviral activity against both X4 tropic and R5 tropic strains, as well as NRTI, NNRTI and PI drug-resistant variants.
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- CAS No.: 280571-30-4
- 화학식: C16H12FN3O3
- 분자량:313.28
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| PBMC | CC50 |
110 μM
Compound: S-1360
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Cytotoxicity against PBMC
Cytotoxicity against PBMC
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[PMID: 22328963] |
Chemical Information
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CAS No. 280571-30-4
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분자량 313.28
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화학식 C16H12FN3O3
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SMILES
O=C(C1=CC=C(CC2=CC=C(C=C2)F)O1)/C=C(C3=NN=CN3)\O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
S 1360 Related Classifications
HY-12108 Related Classifications
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