Santalol
Based on 1 publication(s) in Google Scholar
Santalol is a mixture of α and β-isomer santalol. α-Santalol is found in sandalwood oil. α-Santalol is a promising anti-cancer agent against cancers such as oral, breast, prostate and skin cancer. Santalol has sedative activity .
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- Purity: 74.30%
- CAS No.: 11031-45-1
- 화학식: C15H24O
- 분자량:220.36
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보관:
-20°C, protect from light
* The compound is unstable in solutions, freshly prepared is recommended.
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Santalol
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Biological Activity
α-Santalol and β-Santalol (i.p., 50 mg/kg) decreases spontaneous activity and simultaneously shows motor incoordination, such as catalepsy, but does not cause ptosis, hypnosis and muscle relaxation in male ddY mice [3].
α-Santalol and β-Santalol (i.p., 25 mg/kg, 50 mg/kg) significantly decreases Apomorphine (HY-12723)-induced (2 mg/kg) movements in male ddY mice [3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 11031-45-1
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Appearance Liquid (Density: 0.968 g/cm3)
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분자량 220.36
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화학식 C15H24O
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Color Colorless to light yellow
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SMILES
C=C1[C@@H]2C[C@H]([C@]1(C)CC/C=C(C)\CO)CC2.C[C@@]3(C4([C@H]5CC3CC45)C)CC/C=C(CO)/C.[mixture of a and b-isomer]
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
-20°C, protect from light
* The compound is unstable in solutions, freshly prepared is recommended.
Publications (1)
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Journal Impact Factor
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Most Recent
용액&용해도
DMSO : 50 mg/mL (226.90 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1.25 mg/mL (5.67 mM); Clear solution
This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 1.25 mg/mL (5.67 mM); Suspended solution; Need ultrasonic
This protocol yields a suspended solution of 1.25 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * The compound is unstable in solutions, freshly prepared is recommended.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
순도&문서
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Data Sheet (283 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Bommareddy A, et al. Medicinal properties of alpha-santalol, a naturally occurring constituent of sandalwood oil: review.Nat Prod Res. 2019 Feb;33(4):527-543. [Content Brief]
[3]. Okugawa H, et al. Effect of α-santalol and β-santalol from sandalwood on the central nervous system in mice. Phytomedicine. 1995 Oct;2(2):119-26. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.5380 mL | 22.6901 mL | 45.3803 mL | 113.4507 mL |
| 5 mM | 0.9076 mL | 4.5380 mL | 9.0761 mL | 22.6901 mL | |
| 10 mM | 0.4538 mL | 2.2690 mL | 4.5380 mL | 11.3451 mL | |
| 15 mM | 0.3025 mL | 1.5127 mL | 3.0254 mL | 7.5634 mL | |
| 20 mM | 0.2269 mL | 1.1345 mL | 2.2690 mL | 5.6725 mL | |
| 25 mM | 0.1815 mL | 0.9076 mL | 1.8152 mL | 4.5380 mL | |
| 30 mM | 0.1513 mL | 0.7563 mL | 1.5127 mL | 3.7817 mL | |
| 40 mM | 0.1135 mL | 0.5673 mL | 1.1345 mL | 2.8363 mL | |
| 50 mM | 0.0908 mL | 0.4538 mL | 0.9076 mL | 2.2690 mL | |
| 60 mM | 0.0756 mL | 0.3782 mL | 0.7563 mL | 1.8908 mL | |
| 80 mM | 0.0567 mL | 0.2836 mL | 0.5673 mL | 1.4181 mL | |
| 100 mM | 0.0454 mL | 0.2269 mL | 0.4538 mL | 1.1345 mL |
Santalol Related Classifications
HY-N2059 Related Classifications
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