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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2438 Results for "
decrease
" in MedChemExpress (MCE) Product Catalog:
Products (2438)
2438 Results for "decrease" in MCE Product Catalog:
Cat. No.: HY-158160
CAS No.: 2918263-09-7
Target:
연구분야:
LBA-3 is a selective, orally active inhibitor for sodium-coupled citrate transporter SLC13A5, with an IC50 of 67 nM. LBA-3 decreases levels of triglyceride and total cholesterol in oleic and palmitic acid (OPA)-stimulated AML12 cells, PCN-stimulated primary mouse hepatocytes and in mouse models, without detectable toxicity. LBA-3 is blood-brain barrier permeable .
Cat. No.: HY-17611
CAS No.: 1593673-23-4
Synonyms: MSP-2017; (-)-MSP-2017
Target:
Etripamil (MSP-2017) is a short-acting, L-type calcium-channel antagonist. Etripamil inhibits calcium influx through slow calcium channels, thereby slowing AV node conduction and prolonging the AV node refractory period. Etripamil increases heart rate and decreases systolic blood pressure. Etripamil can be used in the study of paroxysmal supraventricular tachycardia (PSVT) .
Cat. No.: HY-176542
CAS No.: 3030718-42-1
TD034 is a selective, reversible and noncovalent HDAC11 inhibitor with an IC50 of 5.1 nM and a Ki of 1.5 nM. TD034 does not inhibit other HDACs or sirtuins. TD034 inhibits the defatty acylation of SHMT2 (HDAC11 substrate). TD034 decreases the YAP1 level via HDAC11 inhibition. TD034 can be used for the study of lung cancer .
Cat. No.: HY-177916
Target:
연구분야:
DSPE-PEG2000-GNYTCEVTELTREGETIIELK is a PEG compound which composed of DSPE and a peptide mimicking the function of CD47 (GNYTCEVTELTREGETIIELK). Modifying the surface of LNPs with GNYTCEVTELTREGETIIELK significantly reduced the recognition and clearance of LNPs by the mononuclear phagocytic system (MPS), and decreased their accumulation in non-target tissues such as the liver and spleen. DSPE-PEG2000-GNYTCEVTELTREGETIIELK can be used for drug delivery .
Cat. No.: HY-178033
CAS No.: 100611-91-4
Antileishmanial agent-35 (Compound 6) is an antileishmanial agent with an IC50 of 0.29μM for promastigotes of Leishmania amazonensis. Antileishmanial agent-35 significantly decreases the mitochondrial membrane potential and ATP levels, and further increases the production of ROS by a blockage in the electron transport chain, where ubiquinone intervenes. Antileishmanial agent-35 can be used for cutaneous leishmaniases research .
Cat. No.: HY-179669A
Cat. No.: HY-179669B
Cat. No.: HY-182097
Target:
연구분야:
DSPE-PEG1000-GNYTCEVTELTREGETIIELK is a PEG compound which composed of DSPE and a peptide mimicking the function of CD47 (GNYTCEVTELTREGETIIELK). Modifying the surface of LNPs with GNYTCEVTELTREGETIIELK significantly reduced the recognition and clearance of LNPs by the mononuclear phagocytic system (MPS), and decreased their accumulation in non-target tissues such as the liver and spleen. DSPE-PEG1000-GNYTCEVTELTREGETIIELK can be used for drug delivery .
Cat. No.: HY-182097A
Target:
연구분야:
DSPE-PEG3400-GNYTCEVTELTREGETIIELK is a PEG compound which composed of DSPE and a peptide mimicking the function of CD47 (GNYTCEVTELTREGETIIELK). Modifying the surface of LNPs with GNYTCEVTELTREGETIIELK significantly reduced the recognition and clearance of LNPs by the mononuclear phagocytic system (MPS), and decreased their accumulation in non-target tissues such as the liver and spleen. DSPE-PEG3400-GNYTCEVTELTREGETIIELK can be used for drug delivery .
Cat. No.: HY-182097B
Target:
연구분야:
DSPE-PEG5000-GNYTCEVTELTREGETIIELK is a PEG compound which composed of DSPE and a peptide mimicking the function of CD47 (GNYTCEVTELTREGETIIELK). Modifying the surface of LNPs with GNYTCEVTELTREGETIIELK significantly reduced the recognition and clearance of LNPs by the mononuclear phagocytic system (MPS), and decreased their accumulation in non-target tissues such as the liver and spleen. DSPE-PEG5000-GNYTCEVTELTREGETIIELK can be used for drug delivery .
Cat. No.: HY-182581
CAS No.: 862310-66-5
Target:
연구분야:
MK-3134 is an orally active, brain-penetrant and selective histamine H3 receptor inverse agonist. MK-3134 modulates histaminergic neurotransmission, decreases constitutive H3 receptor signaling, releases tonic inhibition of neurotransmitter release, potentiates neurotransmission, and may enhance cholinergic neurotransmission. MK-3134 can be used for the research of Alzheimer's disease .
Cat. No.: HY-183567
CAS No.: 3030492-72-6
연구분야:
Ferroptosis-IN-27 is a glutathione peroxidase (GPx) mimetic. Ferroptosis-IN-27 inhibits oxidative stress, reduces intracellular ROS levels, decreases lipid peroxidation and alleviates ferrous ion overload, thereby inhibiting ferroptosis and protecting cardiomyocytes from Doxorubicin (HY-15142A)-induced injury. Ferroptosis-IN-27 can be used in studies related to Doxorubicin-induced cardiotoxicity .
Cat. No.: HY-184702
연구분야:
Aldose reductase-IN-10 is an inhibitor of aldose reductase with an IC50 of 1.965 μM. Aldose reductase-IN-10 reduces malondialdehyde levels and enhances the activities of SOD, CAT and GPx. Aldose reductase-IN-10 decreases total cholesterol, triglyceride and LDL-C levels, while increasing HDL-C levels. Aldose reductase-IN-10 can be used for the research of diabetic complications .
연구분야:
Potassium perfluorohexanesulfonate is a perfluoroalkyl substance. Potassium perfluorohexanesulfonate binds to FTO with an IC50 of 31.28 mg/L. Potassium perfluorohexanesulfonate induces oxidative stress, mitochondrial depolarization, cytoskeletal disruption, impaired spindle migration, symmetric division, enlarged polar bodies, and decreased developmental competence after parthenogenetic activation. Potassium perfluorohexanesulfonate inhibits pulmonary surfactant function and disrupts the properties of synthetic pulmonary surfactant .
Cat. No.: HY-32351B
CAS No.: 73809-05-9
Synonyms: 3-epi-25-Hydroxy cholecalciferol
Target:
연구분야:
3-epi-25-hydroxy Vitamin D3 is the C-3 epimer of 25-hydroxy vitamin D3.1 Dietary administration of 3-epi-25-hydroxy vitamin D3 (0.5 and 1 IU/g) decreases levels of serum parathyroid hormone (PTH) in male, but not female, weanling rats.
Cat. No.: HY-B0094R
CAS No.: 63968-64-9
Synonyms: Qinghaosu (Standard); NSC 369397 (Standard)
Category:
Plant Terpenoids Sesquiterpenes Artemisia annua Linn. Extract Compositae/Asteraceae Extract
Target:
Synonyms: Cytosine β-D-riboside (Standard); Cytosine-1-β-D-ribofuranoside (Standard)
Cat. No.: HY-B0185AS
CAS No.: 1189959-13-4
Cat. No.: HY-B0185S1
CAS No.: 851528-09-1
Cat. No.: HY-B2099AR
CAS No.: 1190-53-0
Synonyms: 1-Butylbiguanide hydrochloride (Standard)
Target:
연구분야:
Buformin (hydrochloride) (Standard) is the analytical standard of Buformin (hydrochloride). This product is intended for research and analytical applications. Buformin hydrochloride (1-Butylbiguanide hydrochloride), a potent AMPK activator, acts as an orally active biguanide antidiabetic agent. Buformin hydrochloride decreases hepatic gluconeogenesis and lowers blood glucose production in vivo. Buformin hydrochloride also has anti-cancer activities and is applied in cancer study (such as, cervical cancer and breast cancer, et al) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
