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TAU-IN-3

TAU-IN-3 (Compound 2) is an orally active TAU inhibitor. TAU-IN-3 inhibits the expression of MAPT exon 10 DDPAC mutant gene in HeLa cells (IC50: 0.6 µM). TAU-IN-3 reduces the 4R/3R MAPT mRNA ratio in HeLa cells transfected with WT or DDPAC minigenes. TAU-IN-3 inhibits the insertion of endogenous MAPT exon 10 and the production of 4R tau protein in cells. TAU-IN-3 modulates tau splicing in htau mice and improves the associated behavioral phenotypes. TAU-IN-3 can be used to study neurodegenerative diseases.

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  • CAS No.: 3063511-09-8
  • 화학식: C24H30N6O2
  • 분자량:434.53
  • 보관:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • TAU-IN-3 Chemical Structure
    TAU-IN-3 Chemical Structure
CAS No.: 3063511-09-8
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