TLR4 agonist-2
TLR4 agonist-2 is a TLR4 agonist with EC50 values of 0.82 μM and 0.43 μM for mTLR4 and hTLR4, respectively. TLR4 agonist-2 induces the production of TLR4-dependent cytokines and chemokines. TLR4 agonist-2 can be used for immunological research.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- CAS No.: 2148927-98-2
- 화학식: C31H30N4O2S
- 분자량:522.66
-
보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- 순도&문서
- References
-
Help & FAQs
Biological Activity
제품 설명
IC50 & Target
[1]|
hTLR4 0.82 μM (EC50) |
mTLR4 0.43 μM (EC50) |
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | EC50 |
0.43 μM
Compound: 36
|
Agonist activity at human TLR4 expressed in HEK293 blue cells assessed as induction of NF-kappaB activation-mediated SEAP production after 20 to 24 hrs by colorimetric assay
Agonist activity at human TLR4 expressed in HEK293 blue cells assessed as induction of NF-kappaB activation-mediated SEAP production after 20 to 24 hrs by colorimetric assay
|
[PMID: 29049886] |
In Vitro
TLR4 agonist-2 (Compound 36) (5 μM; overnight) potently induces the release of IL-6 and CCL5 from primary mouse bone marrow-derived dendritic cells[1].
TLR4 agonist-2 potently induces the release of IL8 and IL-6 from primary human peripheral blood mononuclear cells[1].
TLR4 agonist-2 (5 μM; overnight) shows no significant toxicity to human hepatocellular carcinoma cells HepG2 at the concentration of 5 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
-
Cell Line:HepG2 human hepatocellular carcinoma cells
-
Concentration:5 μM
-
Incubation Time:overnight
-
Result:Showed no significant difference in cell viability compared to reference compound 1, vehicle control (DMSO), and positive controls (1Y136, LPS).
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:C57BL/6[1]
-
Dosage:20 nmol
-
Administration:i.v.; single dose
-
Result:Induced significantly higher serum levels of the chemokine KC (keratinocyte chemoattractant; CXCL1) and IP-10 at 3 hours post-injection.
Showed a trend toward higher serum IL-6 levels at 3 hours post-injection.
Chemical Information
-
CAS No. 2148927-98-2
-
분자량 522.66
-
화학식 C31H30N4O2S
-
SMILES
CN1C2=CC=C(C=C2C3=C1C(N(C(SCC(NC4CCCCC4)=O)=N3)C5=CC=CC=C5)=O)C6=CC=CC=C6
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TLR4 agonist-2 Related Classifications
HY-186271 Related Classifications
Powered by Bioz
Keywords
- TLR4 agonist-2
- 2148927-98-2
- Toll-like Receptor (TLR)
- human TLR4
- murine TLR4 reporter cells
- HepG2 human hepatocellular carcinoma cells
- LPS binding pocket
- TLR4/MD-2 complex
- primary murine bone marrow-derived dendritic cells
- C57BL/6 mice
- primary human peripheral blood mononuclear cells
- human TLR4 reporter cells
- TLR4 signaling
- Inhibitor
- inhibitor
- inhibit