TLR7 agonist 19
TLR7 agonist 19 (Compound 14) is a Toll-like receptor 7 (TLR7) agonist with excellent pharmacokinetic properties and synergistic antitumor activity.
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- CAS No.: 2682008-42-8
- 화학식: C28H42N8O3
- 분자량:538.68
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| T-cell | IC50 |
>25 μM
Compound: 14
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Cytotoxicity against PHA-activated T-cells (unknown origin) assessed as inhibition of IL-2 induced cell proliferation measured after 72 hrs by MTS assay
Cytotoxicity against PHA-activated T-cells (unknown origin) assessed as inhibition of IL-2 induced cell proliferation measured after 72 hrs by MTS assay
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[PMID: 38352849] |
Chemical Information
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CAS No. 2682008-42-8
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분자량 538.68
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화학식 C28H42N8O3
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SMILES
CCC[C@H](NC1=C(N(CC2=NC=C(C3CCN(C4CCOCC4)CC3)C=C2OC)N=C5)C5=NC(N)=N1)CCO
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocol
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Subcutaneous Cell-Line-Derived Xenograft
Subcutaneous cell-line-derived xenograft (CDX) models are established by implanting cultured human cancer cell lines into immunodeficient mice, where the injected cells form localized tumors that can be monitored in vivo as a measure of tumorigenic potential, growth kinetics, and treatment response. These models are widely used in oncology research because they allow reproducible tumor formation and enable comparative assessment of tumor growth between different cell lines or genetic manipulations in a controlled in vivo microenvironment. Subcutaneous implantation of cancer cells in immunodeficient mice is a standard approach for evaluating tumor growth behavior and therapeutic response across multiple cancer types, including prostate, esophageal, pancreatic, and colon cancer models.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TLR7 agonist 19 Related Classifications
HY-162163 Related Classifications
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