Zodasiran
Based on 1 Customer Validation
Zodasiran (ARO-ANG3) is an siRNA targeting ANGPTL3 that mediates RNAi degradation of ANGPTL3 mRNA, reducing hepatic ANGPTL3 protein synthesis and mRNA expression. Zodasiran can be used in research related to diseases such as atherosclerotic cardiovascular disease and mixed dyslipidemia.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity : 95.26%
- CAS No.: 2232918-66-8
- 화학식: C491H646F13N162O309P43S7
- 분자량:15564.70
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보관:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Biological Activity
제품 설명
IC50 & Target
[1]|
ANGPTL3 |
In Vitro
In Vivo
Zodasiran (ARO-ANG3) reduces serum TG and total cholesterol after a single subcutaneous administration in hApoC3 transgenic mice[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 2232918-66-8
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Appearance Solid
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분자량 15564.70
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화학식 C491H646F13N162O309P43S7
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Color White to off-white
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SMILES
[Zodasiran]
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Synonyms
ARO-ANG3
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선적
Room temperature in continental US; may vary elsewhere.
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보관
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
순도&문서
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Data Sheet (268 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2242 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)