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Zodasiran

(Synonyms: ARO-ANG3)
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Zodasiran is a siRNA targeted to ANGPTL3 in the liver.

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  • Purity : 95.26%
  • CAS No.: 2232918-66-8
  • 화학식: C491H646F13N162O309P43S7
  • 분자량:15564.70
  • 보관:

    -20°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • Zodasiran Chemical Structure
    Zodasiran Chemical Structure
CAS No.: 2232918-66-8
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  • Zodasiran Chemical Structure
    Zodasiran Chemical Structure RNA, ([1'-de(6-amino-9H-purin-9-yl)]dA-(5'→5')-sp-Gm-Cm-Um-Cm-Am-Am-Cm-Am-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)A-(2'-deoxy-2'-fluoro)U-Um-Um-Gm-Am-Um-Cm-Am-Gm-Um-Am-(3'→3')-sp-[1'-de(6-amino-9H-purin-9-yl)]dA), 3'-[O-[cis-4-[(3S,8S)-17-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-3,8-bis[[[2-[2-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]ethoxy]ethyl]amino]carbonyl]-1,6,11-trioxo-15-oxa-2,7,12-triazaheptadec-1-yl]cyclohexyl] hydrogen phosphorothioate], complex with RNA (Um-sp-(2'-deoxy-2'-fluoro)A-sp-Cm-sp-(2'-deoxy-2'-fluoro)U-Gm-(2'-deoxy-2'-fluoro)A-Um-(2'-deoxy-2'-fluoro)C-Am-(2'-deoxy-2'-fluoro)A-Am-(2'-deoxy-2'-fluoro)U-Am-(2'-deoxy-2'-fluoro)U-Gm-(2'-deoxy-2'-fluoro)U-Um-(2'-deoxy-2'-fluoro)G-Am-(2'-deoxy-2'-fluoro)G-sp-Cm) (1:1)
    1/16
  • RNA, ([1'-de(6-amino-9H-purin-9-yl)]dA-(5'→5')-sp-Gm-Cm-Um-Cm-Am-Am-Cm-Am-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)A-(2'-deoxy-2'-fluoro)U-Um-Um-Gm-Am-Um-Cm-Am-Gm-Um-Am-(3'→3')-sp-[1'-de(6-amino-9H-purin-9-yl)]dA), 3'-[O-[cis-4-[(3S,8S)-17-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-3,8-bis[[[2-[2-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]ethoxy]ethyl]amino]carbonyl]-1,6,11-trioxo-15-oxa-2,7,12-triazaheptadec-1-yl]cyclohexyl] hydrogen phosphorothioate], complex with RNA (Um-sp-(2'-deoxy-2'-fluoro)A-sp-Cm-sp-(2'-deoxy-2'-fluoro)U-Gm-(2'-deoxy-2'-fluoro)A-Um-(2'-deoxy-2'-fluoro)C-Am-(2'-deoxy-2'-fluoro)A-Am-(2'-deoxy-2'-fluoro)U-Am-(2'-deoxy-2'-fluoro)U-Gm-(2'-deoxy-2'-fluoro)U-Um-(2'-deoxy-2'-fluoro)G-Am-(2'-deoxy-2'-fluoro)G-sp-Cm) (1:1)