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Cat. No.: HY-174308

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ZSA-215

ZSA-215 is a potent and orally active STING agonist with an EC₅₀ of 3.3 μM. ZSA-215 enhances STING signaling through promoting the phosphorylation of STING and interferon regulatory factor 3 (IRF3) and secretion of IFN-β. ZSA-215 inhibits tumor regression and long-term survival of mice in MC38 colon cancer model. ZSA-215 can be used to the study of colon cancerr.

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화학식: C₁₆H₁₈FNO₅Se
분자량:402.28

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

ZSA-215 Chemical Structure

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

ZSA-215 (Compound 2dr) (0-1.5 μM, 24 h) displays an EC₅₀ as low as 3.3 μM in THP1-Blue ISG cells^[1].
ZSA-215 (0.5-1.5 μM, 24 h) displays best activity for STING^R232 (EC₅₀ = 9.0 μM) and mSTING (EC₅₀ = 9.3 μM) in THP1 cells^[1].
ZSA-215 (6-13 μM, 24 h) dramatically induces the expression of IFN-β in THP1 cells^[1].
ZSA-215 (13-50 μM, 3 h) significantly increases the phosphorylation of STING and IRF3 in THP1-Blue ISG cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ELISA Assay^[1]

Cell Line:

THP1 cells
Concentration:

6 μM, 13 μM
Incubation Time:

24 h
Result:

Enhanced STING signaling through promoting the secretion of IFN-β.

Western Blot Analysis^[1]

Cell Line:

THP1-Blue ISG cells
Concentration:

13 μM, 25 μM, 50 μM
Incubation Time:

3 h
Result:

Significantly increased the phosphorylation of STING and IRF3.

Parmacokinetics

Species	Dose	Route	T_1/2	C_max	CL	AUC	F
Mice^[1]	10 mg/kg	p.o.	1.1 h	20633.3 ng/mL	416.7 mL/h/kg	23835 ng·h/mL	58 %
Mice^[1]	5 mg/kg	i.v.	0.6 h	48366.7 ng/mL	242.2 mL/h/kg	20647.7 ng·h/mL	/

In Vivo

ZSA-215 (Compound dr) (60 mg/kg, p.o., every 3 Days, 2 or 6 doses) dramatically suppresses tumor growth and achieves long-term survival in MC38 tumor model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

MC38 tumor model established in BALB/C female mice (6 weeks)^[1]
Dosage:

60 mg/kg
Administration:

Oral administration (p.o.), every 3 Days, 2 or 6 doses
Result:

Achieved CR and long-term survival of all mice, which significantly exceeded its parental compound ZSA-52 (CR = 60%) in combination with anti-PD-1.
Reached CR and long-term survival of all mice with monotherapy.
Did not show any tumor recurrence during additional 74 days observation (total 157 days observation).
Achieved a 60% complete response (CR) rate in mice following two-dose administration.
Produced a high concentration of IFN-β, IL-6 and CXCL10 in tumor and serum, which outperformed MSA-2.

Related Protocols :

Chemical Information

분자량 402.28
화학식 C₁₆H₁₈FNO₅Se
SMILES

COC1=C(C=C2C([Se]C(C(NC[C@H](C(O)=O)CC)=O)=C2F)=C1)OC
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. 1. Zhao HY et al. Design of an Oral STING Agonist through Intramolecular Hydrogen Bond Ring Mimicking to Achieve Complete Tumor Regression. J Med Chem. 2025 Jun 12;68(11):11365-11385. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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