KRAS G12D inhibitor 3 TFA

Art. -Nr.: HY-115880A Reinheit: 98.18%: Data Sheet
COA

SDS
Handling Instructions
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KRAS G12D inhibitor 3 TFA is a KRAS G12D inhibitor with an IC₅₀ of <500 nM. KRAS G12D inhibitor 3 TFA has antitumor effects (WO2022002102A1; compound 146). KRAS G12D inhibitor 3 (TFA) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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KRAS G12D inhibitor 3 TFA Chemische Struktur

CAS. Nr. : 2757095-12-6

Größe	Verfügbarkeit	Menge
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	Auf Lager	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	Auf Lager	Estimated Time of Arrival: December 31
Solid
5 mg	Auf Lager	Estimated Time of Arrival: December 31
10 mg	Auf Lager	Estimated Time of Arrival: December 31
25 mg	Auf Lager	Estimated Time of Arrival: December 31
50 mg	Angebot einholen
100 mg	Angebot einholen

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Other Forms of KRAS G12D inhibitor 3 TFA:

KRAS G12D inhibitor 3 Angebot einholen

Spezialitätsempfehlungen

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Alle Ras Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen

K-Ras H-Ras N-Ras Ras

Biologische Aktivität
Reinheit & Dokumentation
Verweise
Kundenbewertung

Beschreibung

KRAS G12D inhibitor 3 TFA is a KRAS G12D inhibitor with an IC₅₀ of <500 nM. KRAS G12D inhibitor 3 TFA has antitumor effects (WO2022002102A1; compound 146)^[1]. KRAS G12D inhibitor 3 (TFA) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC₅₀ & Target^[1]

KRas G12D

<500 nM (IC₅₀)

Molekulargewicht

748.11

Formel

C₃₆H₃₂ClF₆N₅O₄

CAS. Nr.

2757095-12-6

Appearance

Solid

Color

Light yellow to yellow

SMILES

C#CC1=C(C=CC2=C1C(C3=C(C4=C(C(N5CC6CCC(N6)C5)=NC(OC[C@@]78CCCN7C[C@@H](C8)F)=N4)C=C3Cl)F)=CC(O)=C2)F.OC(C(F)(F)F)=O

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : ≥ 100 mg/mL (133.67 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.3367 mL	6.6835 mL	13.3670 mL
5 mM	0.2673 mL	1.3367 mL	2.6734 mL
10 mM	0.1337 mL	0.6684 mL	1.3367 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner
Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Reinheit & Dokumentation

Purity: 98.18%

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Data Sheet (272 KB) SDS (252 KB)

COA (252 KB) HNMR (324 KB) CNMR (293 KB) RP-HPLC (244 KB) LCMS (144 KB)

Handling Instructions (2659 KB)

Verweise

[1]. Xing DAI, et al. Quinazoline compounds, preparation methods and uses thereof. WO2022002102A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.3367 mL	6.6835 mL	13.3670 mL	33.4175 mL
	5 mM	0.2673 mL	1.3367 mL	2.6734 mL	6.6835 mL
	10 mM	0.1337 mL	0.6684 mL	1.3367 mL	3.3418 mL
	15 mM	0.0891 mL	0.4456 mL	0.8911 mL	2.2278 mL
	20 mM	0.0668 mL	0.3342 mL	0.6684 mL	1.6709 mL
	25 mM	0.0535 mL	0.2673 mL	0.5347 mL	1.3367 mL
	30 mM	0.0446 mL	0.2228 mL	0.4456 mL	1.1139 mL
	40 mM	0.0334 mL	0.1671 mL	0.3342 mL	0.8354 mL
	50 mM	0.0267 mL	0.1337 mL	0.2673 mL	0.6684 mL
	60 mM	0.0223 mL	0.1114 mL	0.2228 mL	0.5570 mL
	80 mM	0.0167 mL	0.0835 mL	0.1671 mL	0.4177 mL
	100 mM	0.0134 mL	0.0668 mL	0.1337 mL	0.3342 mL