L-Histidinol-d3
L-Histidinol-d3 ((S)-2-Amino-3-(1H-imidazol-5-yl)propan-1-ol-d3) is the deuterium labeled L-Histidinol (HY-W014233). L-Histidinol is an orally active histidyl-tRNA synthetase inhibitor. L-Histidinol interferes with the initiation stage of protein synthesis, thus affecting cell proliferation and metabolism. L-Histidinol has the effect of modulating the sensitivity of tumor cells to chemotherapeutic agents. L-Histidinol reduces the toxicity of certain chemotherapeutic agents to normal tissues and enhance the sensitivity of tumor cells to chemotherapeutic agents.
For research use only. We do not sell to patients.
- Formula: C6H8D3N3O
- Molecular Weight:144.19
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Molecular Weight 144.19
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Formula C6H8D3N3O
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SMILES
OC([2H])([2H])[C@H](CC1=CN=C([2H])N1)N
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Kohnoe S, et al. L-histidinol potentiates hyperthermic cell-killing in-vitro. Int J Oncol. 1993 Nov;3(5):835-9. [Content Brief]
[2]. Warrington RC, et al. L-Histidinol inhibits specifically and reversibly protein and ribosomal RNA synthesis in mouse L cells. J Biol Chem. 1977 Aug 10;252(15):5251-7. [Content Brief]
[3]. Warrington RC, et al. Effects of L-histidinol on the susceptibility of P815 mastocytoma cells to selected anticancer drugs in vitro and in DBA/2J mice. J Natl Cancer Inst. 1987 Jun;78(6):1177-83. [Content Brief]
[4]. Warrington RC, et al. Reversal of the multidrug-resistant phenotype of Chinese hamster ovary cells by L-histidinol. J Natl Cancer Inst. 1989 May 10;81(10):798-803. [Content Brief]
[5]. Warrington RC, et al. L-histidinol protection against cytotoxic action of cytosine arabinoside and 5-fluorouracil in cultured mouse spleen cells. J Natl Cancer Inst. 1982 Feb;68(2):279-86. [Content Brief]
[6]. Zaharko D, et al. L-histidinol: preclinical therapeutic studies in combination with antitumor agents and pharmacokinetic studies in mice. Cancer Res. 1992 Jul 1;52(13):3604-9. [Content Brief]
[7]. Stolfi RL, et al. Chemotherapeutic activity of L-histidinol against spontaneous, autochthonous murine breast tumors. Chemotherapy. 1990;36(6):435-40. [Content Brief]
[8]. Badary OA. L-Histidinol attenuates Fanconi syndrome induced by ifosfamide in rats. Exp Nephrol. 1999 Jul-Aug;7(4):323-7. [Content Brief]
[9]. Warrington RC, et al. L-histidinol improves the selectivity and efficacy of alkylating agents and daunomycin in mice with P388 leukaemia. Br J Cancer. 1989 Nov;60(5):652-6. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
L-Histidinol-d3 Related Classifications
HY-W064342S Related Classifications
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