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Cat. No.: HY-163620

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LHQ490

LHQ490 is a selective FGFR2 inhibitor, with an IC₅₀ of 5.2 nM. LHQ490 efficiently inhibits the proliferation of BaF3-FGFR2 cells with an IC₅₀ value of 1.4 nM. LHQ490 inhibits FGFR2-driven cancer cell proliferation and induces apoptosis of FGFR2-driven cancer cells.

For research use only. We do not sell to patients.

Formula: C₃₀H₃₃FN₆O₂
Molecular Weight:528.62

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

LHQ490 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A204	IC₅₀	683 nM Compound: 9d; LHQ490	Antiproliferation activity against human A204 cells harboring FGFR2 amplification incubated for 72 hrs by CCK8 assay Antiproliferation activity against human A204 cells harboring FGFR2 amplification incubated for 72 hrs by CCK8 assay	[PMID: 38718625]
BaF3	IC₅₀	>1000 nM Compound: 9d; LHQ490	Antiproliferation activity against mouse BaF3 cells incubated for 72 hrs by CCK8 assay Antiproliferation activity against mouse BaF3 cells incubated for 72 hrs by CCK8 assay	[PMID: 38718625]
BaF3	IC₅₀	1.4 nM Compound: 9d; LHQ490	Antiproliferation activity against mouse BaF3 cells expressing FGFR2 incubated for 72 hrs by CCK8 assay Antiproliferation activity against mouse BaF3 cells expressing FGFR2 incubated for 72 hrs by CCK8 assay	[PMID: 38718625]
BaF3	IC₅₀	98.7 nM Compound: 9d; LHQ490	Antiproliferation activity against mouse BaF3 cells expressing FGFR1 incubated for 72 hrs by CCK8 assay Antiproliferation activity against mouse BaF3 cells expressing FGFR1 incubated for 72 hrs by CCK8 assay	[PMID: 38718625]
MDA-MB-453	IC₅₀	>10000 nM Compound: 9d; LHQ490	Antiproliferation activity against human MDA-MB-453 cells harboring FGFR4 Y367C mutant incubated for 72 hrs by CCK8 assay Antiproliferation activity against human MDA-MB-453 cells harboring FGFR4 Y367C mutant incubated for 72 hrs by CCK8 assay	[PMID: 38718625]
RT-112	IC₅₀	1790 nM Compound: 9d; LHQ490	Antiproliferation activity against human RT-112 cells harboring FGFR3-TACC3 incubated for 72 hrs by CCK8 assay Antiproliferation activity against human RT-112 cells harboring FGFR3-TACC3 incubated for 72 hrs by CCK8 assay	[PMID: 38718625]
SNU-16	IC₅₀	12.9 nM Compound: 9d; LHQ490	Antiproliferation activity against human SNU-16 cells harboring FGFR2 amplification incubated for 72 hrs by CCK8 assay Antiproliferation activity against human SNU-16 cells harboring FGFR2 amplification incubated for 72 hrs by CCK8 assay	[PMID: 38718625]

Chemical Information

Molecular Weight 528.62
Formula C₃₀H₃₃FN₆O₂
SMILES

C=CC(NC1=CC=C(C=C1)C2=C(C3=C(N=CN=C3N2C)N)C4=CC=C(C(F)=C4)C5(COC5)N(C(C)C)CC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Li H, et al. Discovery of LHQ490 as a highly selective fibroblast growth factor receptor 2 (FGFR2) inhibitor. Eur J Med Chem. 2024 Jun 5;272:116473.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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