Lupartumab
Based on 1 Customer Validation
Lupartumab (BAY 1112623) is an anti-LYPD3 (C4.4A) monoclonal antibody that can be used for the synthesis of antibody-drug conjugate BAY 1129980 (HY-P99719).
For research use only. We do not sell to patients.
- Purity: 99.52%
- CAS No.: 1640971-88-5
- Molecular Weight:145.5 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Human IgG1 lambda2
Human
LYPD3/C4.4A
LYPD3 (C4.4A) is a GPI-anchored, highly glycosylated membrane protein belonging to the LY6/uPAR family. It normally participates in epithelial migration and wound repair but is highly expressed in various tumors—such as lung cancer, breast cancer, and urothelial carcinoma—where it drives invasion and metastasis via EMT and pro-tumorigenic signaling pathways, making it a marker and a potential therapeutic target.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Human IgG1 lambda
ELISA, FACS, Functional assay
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Immobilized LYPD3/C4.4A Protein, Human can bind Lupartumab. The EC50 for this effect is 4.963 ng/mL. -
Flow cytometric analysis of 1X106 MCF-7 cells with Lupartumab (HY-P99718 red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 lambda1 (HY-P99992, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
Chemical Information
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CAS No. 1640971-88-5
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Appearance Liquid
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Molecular Weight 145.5 kDa
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Color Colorless to light yellow
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SMILES
[Lupartumab]
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Synonyms
BAY 1112623
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (257 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)