LY-289612
LY-289612 is a HIV-1 protease inhibitor, with an IC50 of 1.5 nM.
For research use only. We do not sell to patients.
- CAS No.: 148314-61-8
- Formula: C35H39N5O5
- Molecular Weight:609.71
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 1.5 nM (HIV-1 protease)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CCRF-CEM | ED50 |
23 nM
Compound: 1
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Concentration required for inhibitory activity against CEM cells in a whole cell assay.
Concentration required for inhibitory activity against CEM cells in a whole cell assay.
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10.1016/0960-894X(95)00101-X |
| CCRF-CEM | IC50 |
13.67 ng/mL
Compound: LY-289612
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Compound was tested for whole cell antiviral activity against CEM cell lines
Compound was tested for whole cell antiviral activity against CEM cell lines
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10.1016/S0960-894X(01)80186-4 |
| CCRF-CEM | IC50 |
23 nM
Compound: LY-289612
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Concentration required for antiviral activity using infected CEM cells
Concentration required for antiviral activity using infected CEM cells
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10.1016/S0960-894X(01)80367-X |
| CCRF-CEM | IC50 |
23 nM
Compound: LY-289612
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Concentration required for in vitro antiviral activity against HIV-1 virus infected CEM cells
Concentration required for in vitro antiviral activity against HIV-1 virus infected CEM cells
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10.1016/S0960-894X(01)80368-1 |
| CCRF-CEM | IC50 |
27 nM
Compound: 1
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Antiviral activity in HIV-infected CEM cells using whole cell assay
Antiviral activity in HIV-infected CEM cells using whole cell assay
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10.1016/0960-894X(95)00102-Y |
| MT2 | IC50 |
31.7 ng/mL
Compound: LY-289612
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Compound was tested for whole cell antiviral activity against MT2 cell lines
Compound was tested for whole cell antiviral activity against MT2 cell lines
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10.1016/S0960-894X(01)80186-4 |
| MT2 | IC50 |
52 nM
Compound: LY-289612
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Concentration required for in vitro antiviral activity against HIV-1 virus infected MT2 cells
Concentration required for in vitro antiviral activity against HIV-1 virus infected MT2 cells
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10.1016/S0960-894X(01)80368-1 |
Chemical Information
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CAS No. 148314-61-8
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Molecular Weight 609.71
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Formula C35H39N5O5
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SMILES
O=C(N[C@@H](CC1=CC=CC=C1)[C@H](O)CC2=CC=CC=C2C(NC(C)(C)C)=O)[C@@H](NC(C3=NC4=CC=CC=C4C=C3)=O)CC(N)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LY-289612 Related Classifications
HY-135459 Related Classifications
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