2. Anti-infection Metabolic Enzyme/Protease
  3. HIV Protease
  4. LY-289612

LY-289612 is a HIV-1 protease inhibitor, with an IC50 of 1.5 nM.

For research use only. We do not sell to patients.

LY-289612

LY-289612 Chemical Structure

CAS No. : 148314-61-8

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Description

LY-289612 is a HIV-1 protease inhibitor, with an IC50 of 1.5 nM[1].

IC50 & Target

IC50: 1.5 nM (HIV-1 protease)[1]
Cellular Effect
Cell Line Type Value Description References
CCRF-CEM ED50
23 nM
Compound: 1
Concentration required for inhibitory activity against CEM cells in a whole cell assay.
Concentration required for inhibitory activity against CEM cells in a whole cell assay.
10.1016/0960-894X(95)00101-X
CCRF-CEM IC50
13.67 ng/mL
Compound: LY-289612
Compound was tested for whole cell antiviral activity against CEM cell lines
Compound was tested for whole cell antiviral activity against CEM cell lines
10.1016/S0960-894X(01)80186-4
CCRF-CEM IC50
23 nM
Compound: LY-289612
Concentration required for antiviral activity using infected CEM cells
Concentration required for antiviral activity using infected CEM cells
10.1016/S0960-894X(01)80367-X
CCRF-CEM IC50
23 nM
Compound: LY-289612
Concentration required for in vitro antiviral activity against HIV-1 virus infected CEM cells
Concentration required for in vitro antiviral activity against HIV-1 virus infected CEM cells
10.1016/S0960-894X(01)80368-1
CCRF-CEM IC50
27 nM
Compound: 1
Antiviral activity in HIV-infected CEM cells using whole cell assay
Antiviral activity in HIV-infected CEM cells using whole cell assay
10.1016/0960-894X(95)00102-Y
MT2 IC50
31.7 ng/mL
Compound: LY-289612
Compound was tested for whole cell antiviral activity against MT2 cell lines
Compound was tested for whole cell antiviral activity against MT2 cell lines
10.1016/S0960-894X(01)80186-4
MT2 IC50
52 nM
Compound: LY-289612
Concentration required for in vitro antiviral activity against HIV-1 virus infected MT2 cells
Concentration required for in vitro antiviral activity against HIV-1 virus infected MT2 cells
10.1016/S0960-894X(01)80368-1
Molecular Weight

609.71

Formula

C35H39N5O5
CAS No.
SMILES

O=C(N[C@@H](CC1=CC=CC=C1)[C@H](O)CC2=CC=CC=C2C(NC(C)(C)C)=O)[C@@H](NC(C3=NC4=CC=CC=C4C=C3)=O)CC(N)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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LY-289612 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LY-289612148314-61-8LY289612LY 289612HIV ProteaseHIV-1Inhibitorinhibitorinhibit

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LY-289612
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HY-135459
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