Mal-amido-(CH2COOH)2
Based on 1 Customer Validation
Mal-amido-(CH2COOH)2, compound 7a, is a maleimidoethyl-containing intermediate for hydrophilic ADC linker.
For research use only. We do not sell to patients.
- Purity: 98.58%
- CAS No.: 207613-14-7
- Formula: C11H12N2O7
- Molecular Weight:284.22
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cleavable Linker |
Mal-amido-(CH2COOH)2 is a intermediate for linker. Bivalent doxorubicin (DOX)-dipeptides (16a-c) are finally prepared and conjugated to the monoclonal antibody BR96. The dipeptides are cleaved by lysosomal proteases following internalization of the resulting immunoconjugates[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 207613-14-7
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Appearance Solid
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Molecular Weight 284.22
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Formula C11H12N2O7
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Color White to off-white
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SMILES
O=C(O)CN(CC(O)=O)C(CCN1C(C=CC1=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 83.33 mg/mL (293.19 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.5184 mL | 17.5920 mL | 35.1840 mL | 87.9600 mL |
| 5 mM | 0.7037 mL | 3.5184 mL | 7.0368 mL | 17.5920 mL | |
| 10 mM | 0.3518 mL | 1.7592 mL | 3.5184 mL | 8.7960 mL | |
| 15 mM | 0.2346 mL | 1.1728 mL | 2.3456 mL | 5.8640 mL | |
| 20 mM | 0.1759 mL | 0.8796 mL | 1.7592 mL | 4.3980 mL | |
| 25 mM | 0.1407 mL | 0.7037 mL | 1.4074 mL | 3.5184 mL | |
| 30 mM | 0.1173 mL | 0.5864 mL | 1.1728 mL | 2.9320 mL | |
| 40 mM | 0.0880 mL | 0.4398 mL | 0.8796 mL | 2.1990 mL | |
| 50 mM | 0.0704 mL | 0.3518 mL | 0.7037 mL | 1.7592 mL | |
| 60 mM | 0.0586 mL | 0.2932 mL | 0.5864 mL | 1.4660 mL | |
| 80 mM | 0.0440 mL | 0.2199 mL | 0.4398 mL | 1.0995 mL | |
| 100 mM | 0.0352 mL | 0.1759 mL | 0.3518 mL | 0.8796 mL |
Mal-amido-(CH2COOH)2 Related Classifications
HY-23642 Related Classifications
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