1. Antibody-drug Conjugate/ADC Related
  2. ADC Linker
  3. Mal-amido-(CH2COOH)2

Mal-amido-(CH2COOH)2 

Cat. No.: HY-23642
Handling Instructions

Mal-amido-(CH2COOH)2, compound 7a, is a maleimidoethyl-containing intermediate for hydrophilic ADC linker.

For research use only. We do not sell to patients.

Mal-amido-(CH2COOH)2 Chemical Structure

Mal-amido-(CH2COOH)2 Chemical Structure

CAS No. : 207613-14-7

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Description

Mal-amido-(CH2COOH)2, compound 7a, is a maleimidoethyl-containing intermediate for hydrophilic ADC linker[1].

IC50 & Target

Cleavable

 

In Vitro

Mal-amido-(CH2COOH)2 is a intermediate for linker. Bivalent doxorubicin (DOX)-dipeptides (16a-c) are finally prepared and conjugated to the monoclonal antibody BR96. The dipeptides are cleaved by lysosomal proteases following internalization of the resulting immunoconjugates[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ADC Linker

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

284.22

Formula

C₁₁H₁₂N₂O₇

CAS No.

207613-14-7

SMILES

O=C(O)CN(CC(O)=O)C(CCN1C(C=CC1=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Mal-amido-(CH2COOH)2ADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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Product Name:
Mal-amido-(CH2COOH)2
Cat. No.:
HY-23642
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