1. Antibody-drug Conjugate/ADC Related
  2. ADC Linker
  3. Mal-amido-(CH2COOH)2

Mal-amido-(CH2COOH)2, compound 7a, is a maleimidoethyl-containing intermediate for hydrophilic ADC linker.

For research use only. We do not sell to patients.

Mal-amido-(CH2COOH)2 Chemical Structure

Mal-amido-(CH2COOH)2 Chemical Structure

CAS No. : 207613-14-7

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5 mg USD 310 In-stock
10 mg USD 490 In-stock
25 mg USD 980 In-stock
50 mg USD 1560 In-stock
100 mg USD 2500 In-stock
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Based on 1 publication(s) in Google Scholar

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  • Biological Activity

  • Purity & Documentation

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Description

Mal-amido-(CH2COOH)2, compound 7a, is a maleimidoethyl-containing intermediate for hydrophilic ADC linker[1].

IC50 & Target

Cleavable Linker

 

In Vitro

Mal-amido-(CH2COOH)2 is a intermediate for linker. Bivalent doxorubicin (DOX)-dipeptides (16a-c) are finally prepared and conjugated to the monoclonal antibody BR96. The dipeptides are cleaved by lysosomal proteases following internalization of the resulting immunoconjugates[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ADC Linker

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

284.22

Formula

C11H12N2O7

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CN(CC(O)=O)C(CCN1C(C=CC1=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 83.33 mg/mL (293.19 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5184 mL 17.5920 mL 35.1840 mL
5 mM 0.7037 mL 3.5184 mL 7.0368 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.15%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5184 mL 17.5920 mL 35.1840 mL 87.9600 mL
5 mM 0.7037 mL 3.5184 mL 7.0368 mL 17.5920 mL
10 mM 0.3518 mL 1.7592 mL 3.5184 mL 8.7960 mL
15 mM 0.2346 mL 1.1728 mL 2.3456 mL 5.8640 mL
20 mM 0.1759 mL 0.8796 mL 1.7592 mL 4.3980 mL
25 mM 0.1407 mL 0.7037 mL 1.4074 mL 3.5184 mL
30 mM 0.1173 mL 0.5864 mL 1.1728 mL 2.9320 mL
40 mM 0.0880 mL 0.4398 mL 0.8796 mL 2.1990 mL
50 mM 0.0704 mL 0.3518 mL 0.7037 mL 1.7592 mL
60 mM 0.0586 mL 0.2932 mL 0.5864 mL 1.4660 mL
80 mM 0.0440 mL 0.2199 mL 0.4398 mL 1.0995 mL
100 mM 0.0352 mL 0.1759 mL 0.3518 mL 0.8796 mL
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Mal-amido-(CH2COOH)2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Mal-amido-(CH2COOH)2
Cat. No.:
HY-23642
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