1. Antibody-drug Conjugate/ADC Related
  2. ADC Linker
  3. Mal-amido-(CH2COOH)2

Mal-amido-(CH2COOH)2 

Cat. No.: HY-23642
Handling Instructions

Mal-amido-(CH2COOH)2, compound 7a, is a maleimidoethyl-containing intermediate for hydrophilic ADC linker.

For research use only. We do not sell to patients.

Mal-amido-(CH2COOH)2 Chemical Structure

Mal-amido-(CH2COOH)2 Chemical Structure

CAS No. : 207613-14-7

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Description

Mal-amido-(CH2COOH)2, compound 7a, is a maleimidoethyl-containing intermediate for hydrophilic ADC linker[1].

IC50 & Target

Cleavable

 

In Vitro

Mal-amido-(CH2COOH)2 is a intermediate for linker. Bivalent doxorubicin (DOX)-dipeptides (16a-c) are finally prepared and conjugated to the monoclonal antibody BR96. The dipeptides are cleaved by lysosomal proteases following internalization of the resulting immunoconjugates[1].

In Vivo

ADC Linker

Molecular Weight

284.22

Formula

C₁₁H₁₂N₂O₇

CAS No.

207613-14-7

SMILES

O=C(O)CN(CC(O)=O)C(CCN1C(C=CC1=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Mal-amido-(CH2COOH)2ADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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Mal-amido-(CH2COOH)2
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HY-23642
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