MC-VA-PAB-Exatecan

Name: MC-VA-PAB-Exatecan
Brand: MedChemExpress
SKU: HY-147270
Rating: 4.5 (1 reviews)

Cat. No.: HY-147270 Pureza: 98.88%: Ficha de datos
COA

SDS
Instrucciones de manejo
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Technical Support

MC-VA-PAB-Exatecan is a agent-linker conjugate for ADC. MC-VA-PAB-Exatecan contains the ADC linker (peptide MC-VA-PAB) and a DNA topoisomerase I inhibitor Exatecan (HY-13631). MC-VA-PAB-Exatecan synthesized ADC shows good antitumor activity.

Para uso exclusivo en investigación. No vendemos a pacientes.

MC-VA-PAB-Exatecan Estructura química

No. CAS : 2680543-57-9

Tamaño	Stock	Cantidad
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
50 mg	Obtener un presupuesto
100 mg	Obtener un presupuesto

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This product is a controlled substance and not for sale in your territory.

Revisión del cliente

Based on 1 publication(s) in Google Scholar

1 Publications Citing Use of MCE MC-VA-PAB-Exatecan

•Patent. US20250255982A1.

Recomendaciones destacadas

•Related Small Molecules:

•Related Proteins:

Ver todos los productos específicos de isoformas Drug-Linker Conjugates for ADC:

Ver todas las isoformas

Auristatin Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents Dual payloads

Ver todos los productos específicos de isoformas Topoisomerase:

Ver todas las isoformas

Topoisomerase Topo I Topo II DNA gyrase

Actividad biológica
Pureza y Documentación
Referencias
Revisión del cliente

Descripciòn

IC₅₀ & Target

Camptothecins

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Peso molecular

948.00

Fòrmula

C₅₀H₅₄FN₇O₁₁

No. CAS

2680543-57-9

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C=CC1=O)N1CCCCCC(N[C@@H](C(C)C)C(N[C@@H](C)C(NC(C=C2)=CC=C2COC(N[C@@H]3C4=C5C(C(N6C5)=CC([C@](O)(C(OC7)=O)CC)=C7C6=O)=NC8=CC(F)=C(C)C(CC3)=C84)=O)=O)=O)=O

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvente y solubilidad

In Vitro:

DMF : ≥ 100 mg/mL (105.49 mM)

DMSO : 100 mg/mL (105.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.0549 mL	5.2743 mL	10.5485 mL
5 mM	0.2110 mL	1.0549 mL	2.1097 mL
10 mM	0.1055 mL	0.5274 mL	1.0549 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Pureza y Documentación

Purity: 99.01%

Select Batch:

Ficha de datos (276 KB) SDS (252 KB)

COA (258 KB) HNMR (574 KB) LCMS (102 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. KRAIEM, et al. Treatment of cancer. WO2021151984A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMF / DMSO	1 mM	1.0549 mL	5.2743 mL	10.5485 mL	26.3713 mL
	5 mM	0.2110 mL	1.0549 mL	2.1097 mL	5.2743 mL
	10 mM	0.1055 mL	0.5274 mL	1.0549 mL	2.6371 mL
	15 mM	0.0703 mL	0.3516 mL	0.7032 mL	1.7581 mL
	20 mM	0.0527 mL	0.2637 mL	0.5274 mL	1.3186 mL
	25 mM	0.0422 mL	0.2110 mL	0.4219 mL	1.0549 mL
	30 mM	0.0352 mL	0.1758 mL	0.3516 mL	0.8790 mL
	40 mM	0.0264 mL	0.1319 mL	0.2637 mL	0.6593 mL
	50 mM	0.0211 mL	0.1055 mL	0.2110 mL	0.5274 mL
	60 mM	0.0176 mL	0.0879 mL	0.1758 mL	0.4395 mL
	80 mM	0.0132 mL	0.0659 mL	0.1319 mL	0.3296 mL
	100 mM	0.0105 mL	0.0527 mL	0.1055 mL	0.2637 mL