MC-VC-PABC-amide-PEG1-CH2-CC-885
Based on 1 Customer Validation
MC-VC-PABC-amide-PEG1-CH2-CC-885 (compound I-1) is a neoDegrader-Linker conjugate, consists of the GSPT1 degrader/molecular glue CC-885 (HY-101488) and a linker. MC-VC-PABC-amide-PEG1-CH2-CC-885 can be conjugated to the antibody DAR3.7 that specifically targets CD56 to synthesize Antibody-Drug Conjugates (ADCs).
For research use only. We do not sell to patients.
- Purity: 99.93%
- CAS No.: 2722697-82-5
- Formula: C55H68ClN11O13
- Molecular Weight:1126.65
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Storage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All E3 Ligase Ligand-Linker Conjugates Isoforms
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Biological Activity
neoDegraders is a new class of ADC payloads to specifically degrade intracellular target proteins within target cells. neoDegraders can be utilized in the synthesis of Antibody neoDegrader Conjugates (AnDCs). MC-VC-PABC-amide-PEG1-CH2-CC-885 can also be conjugated to Belantamab (HY-P9980), Daratumumab (HY-P9915), huMy9-6 IgG1, Indatuximab (HY-P990607), Isatuximab (HY-P9976), lintuzumab IgG1, Pertuzumab (HY-P9912), OR000213, Rituximab (HY-P9913), Sacituzumab (HY-P99045), Trastuzumab (HY-P9907)and U3-1784 (HY-P990672) to form conjugates[2][3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2722697-82-5
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Appearance Solid
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Molecular Weight 1126.65
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Formula C55H68ClN11O13
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Color White to off-white
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SMILES
O=C1C2=CC=C(CNC(NC3=CC(Cl)=C(C=C3)CCOCCN(C)C(OCC4=CC=C(C=C4)NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCCN5C(C=CC5=O)=O)=O)=O)=O)=O)=O)C=C2CN1C6C(NC(CC6)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 100 mg/mL (88.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Mary E. Matyskiela, et al. A novel cereblon modulator recruits GSPT1 to the CRL4CRBN ubiquitin ligase. Nature. 2016 Jul 14;535(7611):252-7. [Content Brief]
[2]. Neodegrader conjugates. World Intellectual Property Organization, WO2021198965 A1 2021-10-07.
[3]. Neodegrader conjugates. World Intellectual Property Organization, WO2024075080 A1 2024-04-11.
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.8876 mL | 4.4379 mL | 8.8759 mL | 22.1897 mL |
| 5 mM | 0.1775 mL | 0.8876 mL | 1.7752 mL | 4.4379 mL | |
| 10 mM | 0.0888 mL | 0.4438 mL | 0.8876 mL | 2.2190 mL | |
| 15 mM | 0.0592 mL | 0.2959 mL | 0.5917 mL | 1.4793 mL | |
| 20 mM | 0.0444 mL | 0.2219 mL | 0.4438 mL | 1.1095 mL | |
| 25 mM | 0.0355 mL | 0.1775 mL | 0.3550 mL | 0.8876 mL | |
| 30 mM | 0.0296 mL | 0.1479 mL | 0.2959 mL | 0.7397 mL | |
| 40 mM | 0.0222 mL | 0.1109 mL | 0.2219 mL | 0.5547 mL | |
| 50 mM | 0.0178 mL | 0.0888 mL | 0.1775 mL | 0.4438 mL | |
| 60 mM | 0.0148 mL | 0.0740 mL | 0.1479 mL | 0.3698 mL | |
| 80 mM | 0.0111 mL | 0.0555 mL | 0.1109 mL | 0.2774 mL |
MC-VC-PABC-amide-PEG1-CH2-CC-885 Related Classifications
HY-145448 Related Classifications
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