MC-VC-PABC-amide-PEG1-CH2-CC-885

Name: MC-VC-PABC-amide-PEG1-CH2-CC-885
Brand: MedChemExpress
SKU: HY-145448
Rating: 4.5 (0 reviews)

製品番号: HY-145448 純度: 99.93%: Data Sheet SDS COA 取扱説明書
FAQs
Technical Support

MC-VC-PABC-amide-PEG1-CH2-CC-885 (compound I-1) is a neoDegrader-Linker conjugate, consists of the GSPT1 degrader/molecular glue CC-885 (HY-101488) and a linker. MC-VC-PABC-amide-PEG1-CH2-CC-885 can be conjugated to the antibody DAR3.7 that specifically targets CD56 to synthesize Antibody-Drug Conjugates (ADCs).

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

MC-VC-PABC-amide-PEG1-CH2-CC-885 構造式

CAS 番号 : 2722697-82-5

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 1487	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 1487	在庫あり	Estimated Time of Arrival: December 31
Solid
1 mg	$300	在庫あり	Estimated Time of Arrival: December 31
5 mg	$750	在庫あり	Estimated Time of Arrival: December 31
10 mg	$1200	在庫あり	Estimated Time of Arrival: December 31
25 mg	$2400	在庫あり	Estimated Time of Arrival: December 31
50 mg	$3840	在庫あり	Estimated Time of Arrival: December 31
100 mg	$5950	在庫あり	Estimated Time of Arrival: December 31
200 mg		お問い合わせ
500 mg		お問い合わせ

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* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 0 publication(s) in Google Scholar

E3 Ligase Ligand-Linker Conjugates アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

体外実験

neoDegraders is a new class of ADC payloads to specifically degrade intracellular target proteins within target cells. neoDegraders can be utilized in the synthesis of Antibody neoDegrader Conjugates (AnDCs). MC-VC-PABC-amide-PEG1-CH2-CC-885 can also be conjugated to Belantamab (HY-P9980), Daratumumab (HY-P9915), huMy9-6 IgG1, Indatuximab (HY-P990607), Isatuximab (HY-P9976), lintuzumab IgG1, Pertuzumab (HY-P9912), OR000213, Rituximab (HY-P9913), Sacituzumab (HY-P99045), Trastuzumab (HY-P9907)and U3-1784 (HY-P990672) to form conjugates^[2]^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1126.65

分子式

C₅₅H₆₈ClN₁₁O₁₃

CAS 番号

2722697-82-5

Appearance

Solid

Color

White to off-white

SMILES

O=C1C2=CC=C(CNC(NC3=CC(Cl)=C(C=C3)CCOCCN(C)C(OCC4=CC=C(C=C4)NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCCN5C(C=CC5=O)=O)=O)=O)=O)=O)=O)C=C2CN1C6C(NC(CC6)=O)=O

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (88.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.8876 mL	4.4379 mL	8.8759 mL
5 mM	0.1775 mL	0.8876 mL	1.7752 mL
10 mM	0.0888 mL	0.4438 mL	0.8876 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 99.93%

Select Batch:

データシート (271 KB) SDS (252 KB)

COA (248 KB) HNMR (470 KB) RP-HPLC (267 KB) LCMS (90 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Mary E. Matyskiela, et al. A novel cereblon modulator recruits GSPT1 to the CRL4CRBN ubiquitin ligase. Nature. 2016 Jul 14;535(7611):252-7. [Content Brief]

[2]. Neodegrader conjugates. World Intellectual Property Organization, WO2021198965 A1 2021-10-07.

[3]. Neodegrader conjugates. World Intellectual Property Organization, WO2024075080 A1 2024-04-11.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.8876 mL	4.4379 mL	8.8759 mL	22.1897 mL
	5 mM	0.1775 mL	0.8876 mL	1.7752 mL	4.4379 mL
	10 mM	0.0888 mL	0.4438 mL	0.8876 mL	2.2190 mL
	15 mM	0.0592 mL	0.2959 mL	0.5917 mL	1.4793 mL
	20 mM	0.0444 mL	0.2219 mL	0.4438 mL	1.1095 mL
	25 mM	0.0355 mL	0.1775 mL	0.3550 mL	0.8876 mL
	30 mM	0.0296 mL	0.1479 mL	0.2959 mL	0.7397 mL
	40 mM	0.0222 mL	0.1109 mL	0.2219 mL	0.5547 mL
	50 mM	0.0178 mL	0.0888 mL	0.1775 mL	0.4438 mL
	60 mM	0.0148 mL	0.0740 mL	0.1479 mL	0.3698 mL
	80 mM	0.0111 mL	0.0555 mL	0.1109 mL	0.2774 mL