MC-VC-PABC-amide-PEG1-CH2-CC-885

Name: MC-VC-PABC-amide-PEG1-CH2-CC-885
Brand: MedChemExpress
SKU: HY-145448
Rating: 4.5 (0 reviews)

Cat. No.: HY-145448 Purity: 99.93%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

MC-VC-PABC-amide-PEG1-CH2-CC-885 (compound I-1) is a neoDegrader-Linker conjugate, consists of the GSPT1 degrader/molecular glue CC-885 (HY-101488) and a linker. MC-VC-PABC-amide-PEG1-CH2-CC-885 can be conjugated to the antibody DAR3.7 that specifically targets CD56 to synthesize Antibody-Drug Conjugates (ADCs).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

MC-VC-PABC-amide-PEG1-CH2-CC-885 화학구조

CAS No. : 2722697-82-5

사이즈	재고	수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Solid
1 mg	해외재고보유	Estimated Time of Arrival: December 31
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
200 mg	견적 받기
500 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All E3 Ligase Ligand-Linker Conjugates Isoform Specific Products:

View All Isoforms

von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

Biological Activity
순도&문서
References
고객리뷰

제품 설명

In Vitro

neoDegraders is a new class of ADC payloads to specifically degrade intracellular target proteins within target cells. neoDegraders can be utilized in the synthesis of Antibody neoDegrader Conjugates (AnDCs). MC-VC-PABC-amide-PEG1-CH2-CC-885 can also be conjugated to Belantamab (HY-P9980), Daratumumab (HY-P9915), huMy9-6 IgG1, Indatuximab (HY-P990607), Isatuximab (HY-P9976), lintuzumab IgG1, Pertuzumab (HY-P9912), OR000213, Rituximab (HY-P9913), Sacituzumab (HY-P99045), Trastuzumab (HY-P9907)and U3-1784 (HY-P990672) to form conjugates^[2]^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

1126.65

화학식

C₅₅H₆₈ClN₁₁O₁₃

CAS No.

2722697-82-5

Appearance

Solid

Color

White to off-white

SMILES

O=C1C2=CC=C(CNC(NC3=CC(Cl)=C(C=C3)CCOCCN(C)C(OCC4=CC=C(C=C4)NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCCN5C(C=CC5=O)=O)=O)=O)=O)=O)=O)C=C2CN1C6C(NC(CC6)=O)=O

선적

Room temperature in continental US; may vary elsewhere.

보관

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

용액&용해도

In Vitro:

DMSO : 100 mg/mL (88.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.8876 mL	4.4379 mL	8.8759 mL
5 mM	0.1775 mL	0.8876 mL	1.7752 mL
10 mM	0.0888 mL	0.4438 mL	0.8876 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 99.93%

Select Batch:

Data Sheet (271 KB) SDS (252 KB)

COA (248 KB) HNMR (470 KB) RP-HPLC (267 KB) LCMS (90 KB)

Handling Instructions (2659 KB)

References

[1]. Mary E. Matyskiela, et al. A novel cereblon modulator recruits GSPT1 to the CRL4CRBN ubiquitin ligase. Nature. 2016 Jul 14;535(7611):252-7. [Content Brief]

[2]. Neodegrader conjugates. World Intellectual Property Organization, WO2021198965 A1 2021-10-07.

[3]. Neodegrader conjugates. World Intellectual Property Organization, WO2024075080 A1 2024-04-11.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.8876 mL	4.4379 mL	8.8759 mL	22.1897 mL
	5 mM	0.1775 mL	0.8876 mL	1.7752 mL	4.4379 mL
	10 mM	0.0888 mL	0.4438 mL	0.8876 mL	2.2190 mL
	15 mM	0.0592 mL	0.2959 mL	0.5917 mL	1.4793 mL
	20 mM	0.0444 mL	0.2219 mL	0.4438 mL	1.1095 mL
	25 mM	0.0355 mL	0.1775 mL	0.3550 mL	0.8876 mL
	30 mM	0.0296 mL	0.1479 mL	0.2959 mL	0.7397 mL
	40 mM	0.0222 mL	0.1109 mL	0.2219 mL	0.5547 mL
	50 mM	0.0178 mL	0.0888 mL	0.1775 mL	0.4438 mL
	60 mM	0.0148 mL	0.0740 mL	0.1479 mL	0.3698 mL
	80 mM	0.0111 mL	0.0555 mL	0.1109 mL	0.2774 mL