MS-II-124
Based on 1 Customer Validation
MS-II-124 is an effective and selective NLRP3 inhibitor (IC50=0.12 μM) with anti-inflammatory and immunomodulatory activities, which can be used in the research of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.66%
- CAS 番号: 3037332-85-4
- 分子式: C28H28ClFN2O4S
- 分子量:543.05
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
IC50=0.12 μM (NLRP3)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ALI/ARDS WT C57BL/6 mice model[1].
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Dosage:10 mg/kg
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Administration:Intraperitoneal injection (i.p.), Single dose. 1 h before i.n. instillation of LPS (40 μg in 40 μL PBS).
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Result:Significantly inhibited lipopolysaccharide (LPS)-induced IL-1β production in pulmonary bronchoalveolar lavage fluid (BALF), whereas NLRP3 deletion did not significantly inhibit its production.
化学情報
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CAS 番号 3037332-85-4
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性状 Solid
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分子量 543.05
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分子式 C28H28ClFN2O4S
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Color White to off-white
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SMILES
ClC1=CC=C(OCCC)C(CN(CCC2=CC=C(S(=O)(NCC#C)=O)C=C2)C(C3=CC=C(F)C=C3)=O)=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 35 mg/mL (64.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8415 mL | 9.2073 mL | 18.4145 mL | 46.0363 mL |
| 5 mM | 0.3683 mL | 1.8415 mL | 3.6829 mL | 9.2073 mL | |
| 10 mM | 0.1841 mL | 0.9207 mL | 1.8415 mL | 4.6036 mL | |
| 15 mM | 0.1228 mL | 0.6138 mL | 1.2276 mL | 3.0691 mL | |
| 20 mM | 0.0921 mL | 0.4604 mL | 0.9207 mL | 2.3018 mL | |
| 25 mM | 0.0737 mL | 0.3683 mL | 0.7366 mL | 1.8415 mL | |
| 30 mM | 0.0614 mL | 0.3069 mL | 0.6138 mL | 1.5345 mL | |
| 40 mM | 0.0460 mL | 0.2302 mL | 0.4604 mL | 1.1509 mL | |
| 50 mM | 0.0368 mL | 0.1841 mL | 0.3683 mL | 0.9207 mL | |
| 60 mM | 0.0307 mL | 0.1535 mL | 0.3069 mL | 0.7673 mL |
MS-II-124 関連分類
HY-159159 関連分類
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