MSNBA
Based on 1 publication(s) in Google Scholar
MSNBA is a potent and selective GLUT5 fructose transport inhibitor with an IC50 of 0.10 mM. MSNBA does not affect the transport activity of human GLUT1, GLUT2, GLUT3, GLUT4 or bacterial GlcPSe. MSNBA competitively inhibits GLUT5 fructose uptake with a Ki of 3.2 μM in MCF7 cells. MSNBA can be used for the study of cancer or diabetes.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 97.39%
- CAS 番号: 852702-51-3
- 分子式: C14H12N2O6S
- 分子量:336.32
-
保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
-
溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
-
HY-100017
BAY-876GLUT1 Inhibitor -
HY-145597
KL-11743GLUT1-4 Inhibitor -
HY-10182
LaduviglusibGSK-3 Inhibitor -
HY-10254
MirdametinibMEK Inhibitor -
HY-139605
GLUT inhibitor-1GLUT1/GLUT3 Inhibitor -
HY-145963
DRB18GLUT Inhibitor -
HY-139047
SW157765GLUT8 Inhibitor -
HY-K0202
Protein A/G Magnetic Beads -
HY-158302
GlutorGLUT 1/2/3 Inhibitor -
HY-153612
MMV009085PfHT1 Inhibitor -
HY-149276
SLC26A3-IN-2SLC26A3 Inhibitor
MedChemExpress（MCE）の使用を引用している文献 MSNBA
More
生物活性
製品説明
体外実験
In the presence of 10 mM fructose, MSNBA inhibits fructose uptake in MCF7 cells with an IC50 of 5.8 μM[1].
MSNBA (1-1000 µM; 24 h) significantly decreases the viability of colon cancer cells, while barely affects the viability of normal colon epithelium cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
-
Cell Line:The colon cancer cell line HT-29 and normal colon epithelium CCD 841 CoN cells
-
Concentration:1 µM, 10 µM, 100 µM, 1000 µM
-
Incubation Time:24 h
-
Result:Significantly decreased cell viability of HT-29 cells (51% decrease with 10 µM and 55% with 1 µM MSNBA), while CoN cells were only slightly affected by these concentrations.
化学情報
-
CAS 番号 852702-51-3
-
性状 Solid
-
分子量 336.32
-
分子式 C14H12N2O6S
-
Color Brown to dark brown
-
SMILES
O=[N+](C1=CC(S(=O)(C)=O)=CC=C1NC2=CC3=C(OCO3)C=C2)[O-]
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
Biochem Biophys Res Commun
2026 Mar 12:804:153358. PMID: 41619507
溶剤 & 溶解度
体外:
DMSO : 100 mg/mL (297.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
プロトコル
-
Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
-
Research Protocol for Metabolic Diseases
AMP-activated protein kinase, AMPK, is a conserved cellular energy sensor that responds to reduced cellular energy status and coordinates metabolism by increasing ATP-generating catabolic pathways while suppressing ATP-consuming anabolic processes. In metabolic disease research, the AMPK pathway is experimentally relevant because it regulates hepatic lipid synthesis, fatty acid oxidation, glucose production, skeletal-muscle glucose disposal, mTORC1-linked biosynthesis, autophagy, mitochondrial homeostasis, and whole-body energy balance. The central pathway logic is that energy stress, metformin, exercise-like stimulation, or direct AMPK activators increase AMPKα Thr172 phosphorylation and downstream substrate phosphorylation, including ACC and RAPTOR. Phosphorylation of ACC suppresses lipogenesis and supports fatty acid oxidation, whereas phosphorylation of RAPTOR suppresses mTORC1 signaling and links cellular energy status to growth and protein synthesis control. The pathway is linked
純度とドキュメンテーション
-
データシート (276 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
取扱説明書 (2659 KB)
参考文献
[1]. George Thompson AM, et al. Discovery of a specific inhibitor of human GLUT5 by virtual screening and in vitro transport evaluation. Sci Rep. 2016 Apr 14;6:24240. [Content Brief]
[2]. Włodarczyk J, et al. Blockade of fructose transporter protein GLUT5 inhibits proliferation of colon cancer cells: proof of concept for a new class of anti-tumor therapeutics. Pharmacol Rep. 2021 Jun;73(3):939-945. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9734 mL | 14.8668 mL | 29.7336 mL | 74.3340 mL |
| 5 mM | 0.5947 mL | 2.9734 mL | 5.9467 mL | 14.8668 mL | |
| 10 mM | 0.2973 mL | 1.4867 mL | 2.9734 mL | 7.4334 mL | |
| 15 mM | 0.1982 mL | 0.9911 mL | 1.9822 mL | 4.9556 mL | |
| 20 mM | 0.1487 mL | 0.7433 mL | 1.4867 mL | 3.7167 mL | |
| 25 mM | 0.1189 mL | 0.5947 mL | 1.1893 mL | 2.9734 mL | |
| 30 mM | 0.0991 mL | 0.4956 mL | 0.9911 mL | 2.4778 mL | |
| 40 mM | 0.0743 mL | 0.3717 mL | 0.7433 mL | 1.8583 mL | |
| 50 mM | 0.0595 mL | 0.2973 mL | 0.5947 mL | 1.4867 mL | |
| 60 mM | 0.0496 mL | 0.2478 mL | 0.4956 mL | 1.2389 mL | |
| 80 mM | 0.0372 mL | 0.1858 mL | 0.3717 mL | 0.9292 mL | |
| 100 mM | 0.0297 mL | 0.1487 mL | 0.2973 mL | 0.7433 mL |
MSNBA 関連分類
HY-W179181 関連分類
Powered by Bioz