N-Acetylglyphosate
Based on 1 Customer Validation
N-Acetylglyphosate is an integrin inhibitor and nonherbicide.N-Acetylglyphosate inhibits RGD-dependent integrin αVβ3 binding to vitronectin and RGD-containing substrate and integrin α5β1 binding, with human IC50 values >22 mM for both.N-Acetylglyphosate is the acetylated derivative formed from glyphosate by Gat-mediated acetylation, has no known toxicity in humans or animals, and is a major metabolite in glyphosate-tolerant crops expressing glyphosate N-acetyltransferase.N-Acetylglyphosate can be further metabolized to N-acetyl-AMPA and AMPA, is chemically stable, is not metabolized by plants, and does not effectively inhibit EPSPS.N-Acetylglyphosate does not cause morphological abnormalities in cotton plants.
For research use only. We do not sell to patients.
- Purity : 99.42%
- CAS No.: 129660-96-4
- Formula: C5H10NO6P
- Molecular Weight:211.11
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Storage:
Store at room temperature, keep dry and cool.
In solvent -80°C, 1 year , -20°C, 6 months
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
N-Acetylglyphosate (0.1-22 mM; 1 h) shows very low inhibition of αVβ3 binding to RGD polymers, αVβ3 binding to vitronectin, and α5β1 binding to RGD polymers at 22 mM, and has no inhibitory effect on αIIbβ3 binding to fibrinogen (IC50 >22 mM)[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 129660-96-4
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Appearance Solid
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Molecular Weight 211.11
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Formula C5H10NO6P
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Color Light brown to brown
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SMILES
CC(=O)N(CC(=O)O)CP(=O)(O)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature, keep dry and cool
In solvent -80°C 1 year -20°C 6 months
Solvent & Solubility
In Vitro:
H2O : 100 mg/mL (473.69 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
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Data Sheet (275 KB)
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SDS (555 KB)
- English - EN (555 KB)
- Français - FR (555 KB)
- Deutsch - DE (555 KB)
- Norwegian - NO (555 KB)
- Español - ES (555 KB)
- Swedish - SV (555 KB)
- Italian - IT (555 KB)
- Korean - KR (555 KB)
- Portuguese - PT (555 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 4.7369 mL | 23.6843 mL | 47.3687 mL | 118.4217 mL |
| 5 mM | 0.9474 mL | 4.7369 mL | 9.4737 mL | 23.6843 mL | |
| 10 mM | 0.4737 mL | 2.3684 mL | 4.7369 mL | 11.8422 mL | |
| 15 mM | 0.3158 mL | 1.5790 mL | 3.1579 mL | 7.8948 mL | |
| 20 mM | 0.2368 mL | 1.1842 mL | 2.3684 mL | 5.9211 mL | |
| 25 mM | 0.1895 mL | 0.9474 mL | 1.8947 mL | 4.7369 mL | |
| 30 mM | 0.1579 mL | 0.7895 mL | 1.5790 mL | 3.9474 mL | |
| 40 mM | 0.1184 mL | 0.5921 mL | 1.1842 mL | 2.9605 mL | |
| 50 mM | 0.0947 mL | 0.4737 mL | 0.9474 mL | 2.3684 mL | |
| 60 mM | 0.0789 mL | 0.3947 mL | 0.7895 mL | 1.9737 mL | |
| 80 mM | 0.0592 mL | 0.2961 mL | 0.5921 mL | 1.4803 mL | |
| 100 mM | 0.0474 mL | 0.2368 mL | 0.4737 mL | 1.1842 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
N-Acetylglyphosate Related Classifications
HY-W209596 Related Classifications
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