2. Anti-infection
  3. HIV
  4. NB-64

NB-64 is an orally active HIV-1 inhibitor. NB-64 is promising for research of HIV infections.

For research use only. We do not sell to patients.

NB-64

NB-64 Chemical Structure

CAS No. : 53242-68-5

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NB-64 Related Antibodies

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HIV HIV-1 HIV-2

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Description

NB-64 is an orally active HIV-1 inhibitor. NB-64 is promising for research of HIV infections[1].

IC50 & Target

HIV-1

 

Cellular Effect
Cell Line Type Value Description References
MT2 CC50
335.7 μM
Compound: 1, NB-64
Cytotoxicity against human MT2 cells after 4 days using XTT assay
Cytotoxicity against human MT2 cells after 4 days using XTT assay
[PMID: 22014749]
MT2 CC50
335.72 μM
Compound: A1, NB-64
Cytotoxicity against human MT2 cells after 4 days by XTT assay
Cytotoxicity against human MT2 cells after 4 days by XTT assay
[PMID: 19053778]
MT2 CC50
> 4000 μM
Compound: 15ii, NB-64
Toxicity against human MT2 cells
Toxicity against human MT2 cells
[PMID: 26116177]
MT2 EC50
2.39 μM
Compound: A1, NB-64
Antiviral activity against HIV1 3B in human MT2 cells assessed as inhibition of p24 antigen level after 4 days by ELISA
Antiviral activity against HIV1 3B in human MT2 cells assessed as inhibition of p24 antigen level after 4 days by ELISA
[PMID: 19053778]
MT2 EC50
2.4 μM
Compound: 1, NB-64
Antiviral activity against HIV1 3B infected in human MT2 cells assessed as inhibition of p24 production after 4 days by ELISA
Antiviral activity against HIV1 3B infected in human MT2 cells assessed as inhibition of p24 production after 4 days by ELISA
[PMID: 22014749]
MT2 EC50
29.92 μM
Compound: 15ii, NB-64
Antiviral activity against HIV1 3B assessed as inhibition of virus mediated cell fusion between MT2 cells and H9/HIV1 3B cells
Antiviral activity against HIV1 3B assessed as inhibition of virus mediated cell fusion between MT2 cells and H9/HIV1 3B cells
[PMID: 26116177]
U-87MG ATCC CC50
> 4000 μM
Compound: 15ii, NB-64
Toxicity against human U87-T4-CXCR4 cells
Toxicity against human U87-T4-CXCR4 cells
[PMID: 26116177]
U373-MAGI CC50
> 4000 μM
Compound: 15ii, NB-64
Toxicity against human U373-MAGI-CXCR4-CEM cells
Toxicity against human U373-MAGI-CXCR4-CEM cells
[PMID: 26116177]
Molecular Weight

221.64

Formula

C11H8ClNO2
CAS No.
SMILES

O=C(C1=CC(N2C=CC=C2)=CC=C1Cl)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NB-64 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NB-6453242-68-5NB64NB 64HIVHuman immunodeficiency virusHIV-1HIV infectionsInhibitorinhibitorinhibit

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