1. NF-κB
  2. NF-κB
  3. NF-κB-IN-9

NF-κB-IN-9 is a nuclear factor kappa B (NF-κB) targeting sonosensitizer (λex/λem=489/628 nm). NF-κB-IN-9 exhibits strong inhibition on NF-κB signaling due to its two resveratrol units in one molecule. NF-κB-IN-9 has anti-tumor activity and shows remarkable sonocytotoxicity against cancer cells. NF-κB-IN-9 has biosafety in eenograft mice model.

For research use only. We do not sell to patients.

NF-κB-IN-9 Chemical Structure

NF-κB-IN-9 Chemical Structure

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Description

NF-κB-IN-9 is a nuclear factor kappa B (NF-κB) targeting sonosensitizer (λex/λem=489/628 nm). NF-κB-IN-9 exhibits strong inhibition on NF-κB signaling due to its two resveratrol units in one molecule. NF-κB-IN-9 has anti-tumor activity and shows remarkable sonocytotoxicity against cancer cells. NF-κB-IN-9 has biosafety in eenograft mice model.

In Vitro

NF-κB-IN-9 (TR2) (1 nM-10 μM) shows NO production inhibition with an EC50 value of 68.9 nm in RAW 264.7 macrophages[1].
NF-κB-IN-9 (10 μM; 30 s ultrasonic treatment) inhibits MCF-7 cell proliferation and induces cell apoptosis. NF-κB-IN-9 shows sonocytotoxicity against MCF-7 cells with IC50s of 1.6 μM, 0.55 μM, 0.29 μM for 30 s, 2 min, 5 min ultrasonic treatment time, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

NF-κB-IN-9 (TR2) (1.5 mg/kg; iv; at day 0 and 10, respectively) shows anticancer efficacy and good tolerance in xenograft mouse models. NF-κB-IN-9 can be detected fluorescence in the brain, suggesting that TR2 could penetrate the blood-brain barrier[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MCF-7 xenograft mouse model[1]
Dosage: 1.5 mg/kg
Administration: Intravenous injection at day 0 and 10, respectively
Result: Inhibited tumor growth with no significant decrease in body weight.
Decreased the cytokine levels in the sera of mice by 42%, indicating TR2 induced an anti-inflammatory response.
Molecular Weight

947.15

Formula

C62H50N4O4S

SMILES

COC1=CC(OC)=CC(/C=C/C2=CC=C(C=C2)N(C3=CC=CC=C3)C4=CC=C(C=C4)C5=CC=C(C6=NSN=C65)C7=CC=C(C=C7)N(C8=CC=CC=C8)C9=CC=C(C=C9)/C=C/C%10=CC(OC)=CC(OC)=C%10)=C1

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Room temperature in continental US; may vary elsewhere.

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Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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NF-κB-IN-9 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
NF-κB-IN-9
Cat. No.:
HY-149838
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