2. NF-κB
  3. NF-κB
  4. NF-κB-IN-9

NF-κB-IN-9 is a nuclear factor kappa B (NF-κB) targeting sonosensitizer (λex/λem=489/628 nm). NF-κB-IN-9 exhibits strong inhibition on NF-κB signaling due to its two resveratrol units in one molecule. NF-κB-IN-9 has anti-tumor activity and shows remarkable sonocytotoxicity against cancer cells. NF-κB-IN-9 has biosafety in eenograft mice model.

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NF-κB-IN-9

NF-κB-IN-9 Chemical Structure

CAS No. : 3033815-24-3

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NF-κB-IN-9 Related Antibodies

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Description

NF-κB-IN-9 is a nuclear factor kappa B (NF-κB) targeting sonosensitizer (λex/λem=489/628 nm). NF-κB-IN-9 exhibits strong inhibition on NF-κB signaling due to its two resveratrol units in one molecule. NF-κB-IN-9 has anti-tumor activity and shows remarkable sonocytotoxicity against cancer cells. NF-κB-IN-9 has biosafety in eenograft mice model.

Cellular Effect
Cell Line Type Value Description References
MCF7 IC50
0.29 μM
Compound: TR2
Sono-cytotoxicity against human MCF7 cells assessed as inhibition of cell growth preincubated for 4 hrs followed by ultrasonic sound treatment for 5 mins by MTT assay
Sono-cytotoxicity against human MCF7 cells assessed as inhibition of cell growth preincubated for 4 hrs followed by ultrasonic sound treatment for 5 mins by MTT assay
[PMID: 37075092]
MCF7 IC50
0.55 μM
Compound: TR2
Sono-cytotoxicity against human MCF7 cells assessed as inhibition of cell growth preincubated for 4 hrs followed by ultrasonic sound treatment for 2 mins by MTT assay
Sono-cytotoxicity against human MCF7 cells assessed as inhibition of cell growth preincubated for 4 hrs followed by ultrasonic sound treatment for 2 mins by MTT assay
[PMID: 37075092]
MCF7 IC50
1.6 μM
Compound: TR2
Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth preincubated for 72 hrs followed by ultrasonic sound treatment for 30 sec by MTT assay
Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth preincubated for 72 hrs followed by ultrasonic sound treatment for 30 sec by MTT assay
[PMID: 37075092]
MCF7 IC50
1.6 μM
Compound: TR2
Sono-cytotoxicity against human MCF7 cells assessed as inhibition of cell growth preincubated for 4 hrs followed by ultrasonic sound treatment for 30 sec by MTT assay
Sono-cytotoxicity against human MCF7 cells assessed as inhibition of cell growth preincubated for 4 hrs followed by ultrasonic sound treatment for 30 sec by MTT assay
[PMID: 37075092]
MCF7 IC50
2.4 μM
Compound: TR2
Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 37075092]
RAW264.7 EC50
68.9 nM
Compound: TR2
Inhibition of LPS-stimulated NO production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent based microplate reader analysis
Inhibition of LPS-stimulated NO production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent based microplate reader analysis
[PMID: 37075092]
In Vitro

NF-κB-IN-9 (TR2) (1 nM-10 μM) shows NO production inhibition with an EC50 value of 68.9 nm in RAW 264.7 macrophages[1].
NF-κB-IN-9 (10 μM; 30 s ultrasonic treatment) inhibits MCF-7 cell proliferation and induces cell apoptosis. NF-κB-IN-9 shows sonocytotoxicity against MCF-7 cells with IC50s of 1.6 μM, 0.55 μM, 0.29 μM for 30 s, 2 min, 5 min ultrasonic treatment time, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NF-κB-IN-9 Related Antibodies
In Vivo

NF-κB-IN-9 (TR2) (1.5 mg/kg; iv; at day 0 and 10, respectively) shows anticancer efficacy and good tolerance in xenograft mouse models. NF-κB-IN-9 can be detected fluorescence in the brain, suggesting that TR2 could penetrate the blood-brain barrier[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MCF-7 xenograft mouse model[1]
Dosage: 1.5 mg/kg
Administration: Intravenous injection at day 0 and 10, respectively
Result: Inhibited tumor growth with no significant decrease in body weight.
Decreased the cytokine levels in the sera of mice by 42%, indicating TR2 induced an anti-inflammatory response.
Molecular Weight

947.15

Formula

C62H50N4O4S
CAS No.
SMILES

COC1=CC(OC)=CC(/C=C/C2=CC=C(C=C2)N(C3=CC=CC=C3)C4=CC=C(C=C4)C5=CC=C(C6=NSN=C65)C7=CC=C(C=C7)N(C8=CC=CC=C8)C9=CC=C(C=C9)/C=C/C%10=CC(OC)=CC(OC)=C%10)=C1
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Purity & Documentation
References
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NF-κB-IN-9 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NF-κB-IN-93033815-24-3NF-κBNuclear factor-κBNuclear factor-kappaBInhibitorinhibitorinhibit

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