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Cat. No.: HY-149838

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NF-κB-IN-9

NF-κB-IN-9 is a nuclear factor kappa B (NF-κB) targeting sonosensitizer (λex/λem=489/628 nm). NF-κB-IN-9 exhibits strong inhibition on NF-κB signaling due to its two resveratrol units in one molecule. NF-κB-IN-9 has anti-tumor activity and shows remarkable sonocytotoxicity against cancer cells. NF-κB-IN-9 has biosafety in eenograft mice model.

For research use only. We do not sell to patients.

CAS No.: 3033815-24-3
Formula: C₆₂H₅₀N₄O₄S
Molecular Weight:947.15

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

NF-κB-IN-9 Chemical Structure

CAS No.: 3033815-24-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

All NF-κB Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
MCF7	IC₅₀	0.29 μM Compound: TR2	Sono-cytotoxicity against human MCF7 cells assessed as inhibition of cell growth preincubated for 4 hrs followed by ultrasonic sound treatment for 5 mins by MTT assay Sono-cytotoxicity against human MCF7 cells assessed as inhibition of cell growth preincubated for 4 hrs followed by ultrasonic sound treatment for 5 mins by MTT assay	[PMID: 37075092]
MCF7	IC₅₀	0.55 μM Compound: TR2	Sono-cytotoxicity against human MCF7 cells assessed as inhibition of cell growth preincubated for 4 hrs followed by ultrasonic sound treatment for 2 mins by MTT assay Sono-cytotoxicity against human MCF7 cells assessed as inhibition of cell growth preincubated for 4 hrs followed by ultrasonic sound treatment for 2 mins by MTT assay	[PMID: 37075092]
MCF7	IC₅₀	1.6 μM Compound: TR2	Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth preincubated for 72 hrs followed by ultrasonic sound treatment for 30 sec by MTT assay Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth preincubated for 72 hrs followed by ultrasonic sound treatment for 30 sec by MTT assay	[PMID: 37075092]
MCF7	IC₅₀	1.6 μM Compound: TR2	Sono-cytotoxicity against human MCF7 cells assessed as inhibition of cell growth preincubated for 4 hrs followed by ultrasonic sound treatment for 30 sec by MTT assay Sono-cytotoxicity against human MCF7 cells assessed as inhibition of cell growth preincubated for 4 hrs followed by ultrasonic sound treatment for 30 sec by MTT assay	[PMID: 37075092]
MCF7	IC₅₀	2.4 μM Compound: TR2	Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 37075092]
RAW264.7	EC₅₀	68.9 nM Compound: TR2	Inhibition of LPS-stimulated NO production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent based microplate reader analysis Inhibition of LPS-stimulated NO production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent based microplate reader analysis	[PMID: 37075092]

In Vitro

NF-κB-IN-9 (TR2) (1 nM-10 μM) shows NO production inhibition with an EC₅₀ value of 68.9 nm in RAW 264.7 macrophages^[1].
NF-κB-IN-9 (10 μM; 30 s ultrasonic treatment) inhibits MCF-7 cell proliferation and induces cell apoptosis. NF-κB-IN-9 shows sonocytotoxicity against MCF-7 cells with IC₅₀s of 1.6 μM, 0.55 μM, 0.29 μM for 30 s, 2 min, 5 min ultrasonic treatment time, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

NF-κB-IN-9 (TR2) (1.5 mg/kg; iv; at day 0 and 10, respectively) shows anticancer efficacy and good tolerance in xenograft mouse models. NF-κB-IN-9 can be detected fluorescence in the brain, suggesting that TR2 could penetrate the blood-brain barrier^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

MCF-7 xenograft mouse model^[1]
Dosage:

1.5 mg/kg
Administration:

Intravenous injection at day 0 and 10, respectively
Result:

Inhibited tumor growth with no significant decrease in body weight.
Decreased the cytokine levels in the sera of mice by 42%, indicating TR2 induced an anti-inflammatory response.

Chemical Information

CAS No. 3033815-24-3
Molecular Weight 947.15
Formula C₆₂H₅₀N₄O₄S
SMILES

COC1=CC(OC)=CC(/C=C/C2=CC=C(C=C2)N(C3=CC=CC=C3)C4=CC=C(C=C4)C5=CC=C(C6=NSN=C65)C7=CC=C(C=C7)N(C8=CC=CC=C8)C9=CC=C(C=C9)/C=C/C%10=CC(OC)=CC(OC)=C%10)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Li Y, et al. Design of Sonosensitizers Integrated with Resveratrol Motif for Synergetic Sonodynamic Therapy and Nuclear Factor Kappa B Transcription Suppression of Breast Cancer. J Med Chem. 2023 Apr 19. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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