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Cat. No.: HY-184769

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NK3R antagonist-2

NK3R antagonist-2 (Compound 45) is a small-molecule antagonist of tachykinin NK3R, with an IC₅₀ of 1100 nM and a K_i of 1800 nM. NK3R antagonist-2 can be used in the research of schizophrenia.

For research use only. We do not sell to patients.

CAS No.: 909856-46-8
Formula: C₂₁H₂₀ClN₃O₃
Molecular Weight:397.86

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

NK3R antagonist-2 Chemical Structure

CAS No.: 909856-46-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

Chemical Information

CAS No. 909856-46-8
Molecular Weight 397.86
Formula C₂₁H₂₀ClN₃O₃
SMILES

O=C(C1=NOC(=C1)C=2C=CC(Cl)=CC2)N3CCN(C=4C=CC=CC4OC)CC3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Hoveyda HR, et al. Discovery of 3-aryl-5-acylpiperazinyl-pyrazoles as antagonists to the NK3 receptor. Bioorganic & medicinal chemistry letters. 2011 Apr 01;21(7):1991-6. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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