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Cat. No.: HY-184909

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AI10-a2

AI10-a2 is a tyrosinase (tyrosinase) inhibitor, with IC₅₀ values of 0.92 μM against mushroom tyrosinase using L-DOPA (HY-N0304) as the substrate and 0.68 μM using L-Tyrosine (HY-N0473) as the substrate. AI10-a2 inhibits intracellular melanin (melanin) production and reduces head pigmentation in zebrafish embryos. AI10-a2 can be used for the research of hyperpigmentation disorders.

For research use only. We do not sell to patients.

Formula: C₁₉H₂₃N₃O₃
Molecular Weight:341.40

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

AI10-a2 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

In Vitro

AI10-a2 (12.5-100 μM) inhibits melanogenesis in B16F10 cells stimulated by Melanotan (MT)-II (HY-P0267) in a dose-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

In Vivo

AI10-a2 (30-60 μM; immersion; continuous; 45 hours) exhibits measurable in vivo antimelanogenic activity in zebrafish embryos at 60 μM, with a depigmentation efficacy of 12.68%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

wild-type AB strain (embryos at 6 h postfertilization)^[1]
Dosage:

30 μM; 60 μM
Administration:

immersion; continuous; 45 h
Result:

Achieved a depigmentation efficacy of 12.68% at 60 μM.
Showed minimal to negligible toxicity in treated embryos.

Chemical Information

Molecular Weight 341.40
Formula C₁₉H₂₃N₃O₃
SMILES

CC1=CC(C(N2CCN(CC2)CC3=CC=C(C=C3O)O)=O)=CC(C)=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Pizzorno J, et al. Health Medicine. Integrative medicine (Encinitas, Calif.). 2022 Dec;21(6):8-14. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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