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Cat. No.: HY-N20681

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Evofolin A

Evofolin A is a conjugated benzophenone derivative and monocyclic polyketide that exists in the heartwood of Phellodendron chinense var. glabriusculum, the herb Sida acuta, and the filamentous fungus Aspergillus oryzae. Evofolin A acts as an inducer of quinone reductase activity in cultured hepatoma cells.

For research use only. We do not sell to patients.

CAS No.: 168146-21-2
Formula: C₁₀H₁₂O₄
Molecular Weight:196.20

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Evofolin A Chemical Structure

CAS No.: 168146-21-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

Microbial Metabolite

All Endogenous Metabolite Isoforms :

In Vitro

Evofolin A (6 days) production in Aspergillus oryzae requires the ppsA and ppsB genes, while ppsC enhances Evofolin A yield, and ppsD is not involved in Evofolin A biosynthesis^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 168146-21-2
Molecular Weight 196.20
Formula C₁₀H₁₂O₄
SMILES

C[C@H](O)C(C1=CC(OC)=C(C=C1)O)=O
Structure Classification
- Phenols
- Monophenols
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Animals and Diseases

Liver Cancer Modeling
Liver cancer can be classified into primary liver cancer and secondary liver cancer. Secondary liver cancer is the metastatic liver cancer. Primary liver cancer includes hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC) and fibrolamellar HCC, of which HCC is the most common form, accounting for approximately 90% of primary liver cancers^[1]. HCC mouse models include chemical agent-induced models, transplanted tumor models, and genetic engineered models.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wu T S, et al. The heartwood constituents of Tetradium glabrifolium[J]. Phytochemistry, 1995, 40(1): 121-124.

[2]. Kan E, et al. Discovery of the 2,4'-Dihydroxy-3'-methoxypropiophenone Biosynthesis Genes in Aspergillus oryzae. Chembiochem : a European journal of chemical biology. 2021 Jan 05;22(1):203-211. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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