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Cat. No.: HY-P1209

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PG106

PG106 is a potent and selective human melanocortin 3 (hMC3) receptor antagonist (IC₅₀=210 nM) and has noactivity at hMC4 receptors (EC₅₀=9900 nM) and hMC5 receptor.

For research use only. We do not sell to patients.

CAS No.: 944111-22-2
Formula: C₅₁H₆₉N₁₃O₉
Molecular Weight:1008.18

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PG106 Chemical Structure

CAS No.: 944111-22-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

PG106 is a potent and selective human melanocortin 3 (hMC3) receptor antagonist (IC₅₀=210 nM) and has noactivity at hMC4 receptors (EC₅₀=9900 nM) and hMC5 receptor^[1].

IC₅₀ & Target

IC50: 210 nM (hMC3 receptor)
EC50: 9900 nM (hMC4 receptor)^[1]

All Melanocortin Receptor Isoforms :

Chemical Information

CAS No. 944111-22-2
Molecular Weight 1008.18
Formula C₅₁H₆₉N₁₃O₉
Sequence Shortening

Ac-{Nle}-D-{Bal}-{D-Nal}-RWK-NH2 (Lactam bridge:Asp2-Lys7)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (257 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Paolo Grieco, et al. Further structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5. Peptides [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Protocols
Purity & Documentation
References

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PG106

All Melanocortin Receptor Isoforms

Biological Activity

Description

IC50 & Target

Chemical Information

Protocols

Purity & Documentation

References

Calculators

Help & FAQs

PG106 Related Classifications

HY-P1209 Related Classifications

Bioz

Keywords

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