Complement System
The complement system, composed of more than 30 serum and cell surface components, is collaborating in recognition and elimination of pathogens as a part of both the innate and acquired immune systems. Once the complement system is activated, a chain of reactions involving proteolysis and assembly occurs, resulting in cleavage of the third complement component (C3). The cascade up to C3 cleavage is called the activation pathway. There are three activation pathways: the classical, lectin, and alternative pathways.
The complement cascade is a dual-edged sword, causing protection against bacterial and viral invasion by promoting phagocytosis and inflammation. Pathologically, complement can cause substantial damage to blood vessels (vasculitis), kidney basement membrane and attached endothelial and epithelial cells (nephritis), joint synovium (arthritis), and erythrocytes (hemolysis) if it is not adequately controlled.
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Complement System Inhibitors
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Complement System Agonists
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Complement System Antagonists
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Complement System Activators
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Complement System Modulator
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Complement System Controls
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Complement System Ligands
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Complement System Proteins
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Complement System Related Products (211)
Related Products (211)
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Recombinant Proteins (113)
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Antibodies (7)
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Factor B-IN-2
0 ImagesCat. No.: HY-147604CAS No.: 2760669-72-3Factor B-IN-2 (Example 1 target compound) is a potent complement factor B inhibitor, with an IC50 of 1.5 μM. Factor B-IN-2 can be used for the research of diseases related to inflammation and immunity.
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Tubulin/NRP1-IN-1
0 ImagesCat. No.: HY-163062CAS No.: 2983719-82-8Tubulin/NRP1-IN-1 (compound TN-2) is a dual inhibitor of Tubulin and NRP1 with IC50s of 0.71 and 0.85 μM, respectively. Tubulin/NRP1-IN-1 significantly inhibits the viability of prostate tumor cell lines and induces apoptosis.
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Cevolisiran sodium
0 ImagesCat. No.: HY-177621ACevolisiran sodium, a siRNA, is a complement component 3 (C3) synthesis reducer.
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C5aR1 antagonist 2
0 ImagesCat. No.: HY-163379CAS No.: 2365161-92-6C5aR1 antagonist 2 (Compound 6a) is an orally active C5a receptor 1 (C5aR1) antagonist that shows efficacy in inhibiting the C5a-induced neutrophil count increase. C5aR1 antagonist 2 is potent in the DISCO and migration assays, with IC50 values of 21 and 3 nM, respectively. C5aR1 antagonist 2 can be used for the research of acute and chronic inflammatory diseases.
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Avacincaptad pegol sodium scrambled negative control
0 ImagesCat. No.: HY-147080BAvacincaptad pegol sodium scrambled negative control is the sequence scrambled negative control of Avacincaptad pegol sodium.
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Agazisiran sodium
0 ImagesCat. No.: HY-177611AAgazisiran sodium, a siRNA,is a complement factor B synthesis reducer.
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3-O-(2'E,4'Z-Decadienoyl)ingenol
0 ImagesCat. No.: HY-N7166CAS No.: 84680-59-13-O-(2'E,4'Z-Decadienoyl)ingenol is a natural diterpene that exhibits significant anticomplement activity with an IC50 of 89.5 μM.
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Tarvicopan
0 ImagesCat. No.: HY-172239CAS No.: 2378381-06-5Tarvicopan is an inhibitor for complement factor D.
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Anti-CD88/C5AR1 Antibody (G2_anti-C5aR)
0 ImagesCat. No.: HY-P991485Anti-CD88/C5AR1 Antibody (G2_anti-C5aR) is a human monoclonal antibody (mAb) targeting C5AR1.
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Cevolisiran sodium scrambled negative control
0 ImagesCat. No.: HY-177621BCevolisiran sodium scrambled negative control is the sequence scrambled negative control of Cevolisiran sodium.
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Dexamethasone-d5-1
0 ImagesCat. No.: HY-14648S1Synonyms: Hexadecadrol-d5-1; Prednisolone F-d5-1Dexamethasone-d5-1 is deuterium labeled Dexamethasone. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.
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Cevolisiran
0 ImagesCat. No.: HY-177621CAS No.: 3069641-77-3Cevolisiran, a siRNA, is a complement component 3 (C3) synthesis reducer.
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MEDI7814
0 ImagesCat. No.: HY-P991657MEDI7814 is a humanized monoclonal antibody inhibitor targeting C5a and C5adesArg. MEDI7814 binds to recombinant human C5a and serum purified human C5a with affinities of 14 pM and 8 pM, respectively. MEDI7814 is acute inflammatory diseases such as sepsis and renal ischemia-reperfusion injury.
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Avacopan (Standard)
0 ImagesSynonyms: CCX168 (Standard)Avacopan (Standard) is the analytical standard of Avacopan. This product is intended for research and analytical applications. Avacopan (CCX168) is a potent, selective and orally available complement 5a receptor (C5aR) inhibitor with an IC50 of 0.1 nM.
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Bisphenol A bissulfate disodium
0 ImagesCat. No.: HY-W587516CAS No.: 10040-44-5Bisphenol A bissulfate disodium is a metabolite of Bisphenol A (HY-18260). Bisphenol A bissulfate disodium (compound 7) show complement-inhibiting activity with an IC50 of 247 μM.
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Bisphenol S disulfate disodium
0 ImagesCat. No.: HY-W727837CAS No.: 847696-49-5Bisphenol S disulfate disodium has an inhibitory effect on complement (IC50 = 660 μM) .
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Complement factor D-IN-1 (Standard)
0 ImagesCat. No.: HY-102034RCAS No.: 1386455-76-0Complement factor D-IN-1 (Standard) is the analytical standard of Complement factor D-IN-1 (HY-102034). This product is intended for research and analytical applications. Complement factor D-IN-1 is a potent and selective small-molecule reversible factor d inhibitor, with IC50s of 0.006 and 0.05 μM in FD Thioesterolytic Fluorescent Assay and a MAC Deposition Assay, respectively.
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ACT-1014-6470
0 ImagesCat. No.: HY-157472CAS No.: 2363082-87-3ACT-1014-6470 is an orally active, potent, reversible, and selective C5aR1 antagonist. ACT-1014-6470 demonstrates potent inhibition of C5aR1 activation. ACT-1014-6470 can be used in the research of inflammatory diseases.
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C5aR2 agonist P32 acetate
0 ImagesCat. No.: HY-P10639AC5aR2 agonist P32 (Ac-RHYPYWR-OH) acetate is a C5aR2-selective agonist. C5aR2 agonist P32 acetate has been shown to elicit multiple immunomodulatory activities, both by down-regulating the C5aR1-mediated cell signalling, and acting in a C5aR1-independent fashion, in vitro and in vivo.
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Zilucoplan (PEG2)
0 ImagesCat. No.: HY-P3502BZilucoplan (PEG2) is a Zilucoplan (HY-P3502) derivative, where the linker section replaces PEG24 by PEG2. Zilucoplan is a potent complement component 5 (C5) inhibitor.
