Cat. No.: HY-121204

Iberverin

(Synonyms: 3-Methylthiopropyl isothiocyanate)

Customer Review

Based on 1 Customer Validation

Iberverin (-Methylthiopropyl isothiocyanate) is a sulforaphane homolog. Iberverin has anticancer activity. Iberverin inhibits cell proliferation and migration. Iberverin induces mitochondrial-related apoptosis and intracellular reactive oxygen species.

For research use only. We do not sell to patients.

Purity: 98.0%
CAS No.: 505-79-3
Formula: C₅H₉NS₂
Molecular Weight:147.26

Storage:

Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Iberverin Chemical Structure

CAS No.: 505-79-3

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

Iberverin (0-200 μM, 48 h) inhibits the viability and proliferation of HCC cells, with IC₅₀s less than 25 μM for Huh7, Huh7.5.1, and SNU739^[1].
Iberverin (10 μM, 24-72 h) inhibits migration and invasion in Huh7, Huh7.5.1 and SNU739 cells^[1].
Iberverin (40 μM, 12 h) induces mitochondrial-related apoptosis, induces DNA damage and causes G2/M cell cycle arrest in Huh7, Huh7.5.1 and SNU739 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

Huh7, Huh7.5.1 and SNU739 cells
Concentration:

40 μM
Incubation Time:

12 h
Result:

Enhanced the level of apoptotic protein Bax but repressed the expression of Bcl-2.

In Vivo

Iberverin (20 mg/kg, i.p., every 3 days for five cycles) inhibits the growth of HCC xenograft tumor in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Huh7.5.1 cells were subcutaneously injected into immunodeficient BALB/c nude mice^[1]
Dosage:

20 mg/kg
Administration:

i.p., every 3 days for five cycles
Result:

Reduction the tumor size by 73.4% and weight by 55.3% of Huh7.5.1 xenograft tumors, with no systematic toxicity.
Decreased Ki-67 and PCNA level in tumor.

Chemical Information

CAS No. 505-79-3
Appearance Liquid (Density: 1.05±0.1 g/cm³)
Molecular Weight 147.26
Formula C₅H₉NS₂
Color Colorless to light yellow
SMILES

CSCCCN=C=S
Synonyms

3-Methylthiopropyl isothiocyanate
Structure Classification
- Others
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (679.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

6.7907 mL

33.9536 mL

67.9071 mL

5 mM

1.3581 mL

6.7907 mL

13.5814 mL

10 mM

0.6791 mL

3.3954 mL

6.7907 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
SDS (627 KB)
- English - EN (627 KB)
- Français - FR (627 KB)
- Deutsch - DE (627 KB)
- Norwegian - NO (627 KB)
- Español - ES (627 KB)
- Swedish - SV (627 KB)
- Italian - IT (627 KB)
- Korean - KR (627 KB)
- Portuguese - PT (627 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. 1. Zhang Y, et al. Iberverin exhibits antineoplastic activities against human hepatocellular carcinoma via DNA damage-mediated cell cycle arrest and mitochondrial-related apoptosis. Front Pharmacol. 2023 Dec 13;14:1326346. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	6.7907 mL	33.9536 mL	67.9071 mL	169.7678 mL
	5 mM	1.3581 mL	6.7907 mL	13.5814 mL	33.9536 mL
	10 mM	0.6791 mL	3.3954 mL	6.7907 mL	16.9768 mL
	15 mM	0.4527 mL	2.2636 mL	4.5271 mL	11.3179 mL
	20 mM	0.3395 mL	1.6977 mL	3.3954 mL	8.4884 mL
	25 mM	0.2716 mL	1.3581 mL	2.7163 mL	6.7907 mL
	30 mM	0.2264 mL	1.1318 mL	2.2636 mL	5.6589 mL
	40 mM	0.1698 mL	0.8488 mL	1.6977 mL	4.2442 mL
	50 mM	0.1358 mL	0.6791 mL	1.3581 mL	3.3954 mL
	60 mM	0.1132 mL	0.5659 mL	1.1318 mL	2.8295 mL
	80 mM	0.0849 mL	0.4244 mL	0.8488 mL	2.1221 mL
	100 mM	0.0679 mL	0.3395 mL	0.6791 mL	1.6977 mL

Keywords

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

Iberverin

Apoptosis Compound Library

Immunology/Inflammation Compound Library

Metabolism/Protease Compound Library

NF-κB Signaling Compound Library

Natural Product Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Medicine Food Homology Compound Library

Traditional Chinese Medicine Active Compound Library

Food Additive Library

Food-Sourced Compound Library

Anti-Cancer Natural Product Library

Anti-inflammatory Traditional Chinese Medicine Active Compound Library

Plant-Sourced Natural Product Library

Human Metabolite Library

Cysteine Targeted Covalent Fragment Library

Cell Death Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

Flavor Compound Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Mass Spectrometry Human Metabolite Library

Diarrhea-Related Traditional Chinese Medicine Active Compound Library

Mongolian Medicine Compound Library

Flavors and Fragrances Compound Library

Natural Product Diversity Scaffold Library

Lactylation Compound Library

Mass Spectrometry Natural Product Library

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Iberverin Related Classifications

HY-121204 Related Classifications