JPHM-2-167
JPHM-2-167 (Compound 11) is a selective PHD (prolyl hydroxylase domain enzyme) inhibitor. JPHM-2-167 inhibits PHD2, PHD3 with IC50s of 0.253 μM and 3.95 μM, respectively. JPHM-2-167 can be used for chronic kidney disease .
For research use only. We do not sell to patients.
- CAS No.: 1258877-17-6
- Formula: C30H28N6O2
- Molecular Weight:504.58
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Sf9 | IC50 |
2.1 nM
Compound: 6d
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Inhibition of FLAG-tagged PHD2 expressed in baculovirus infected insect sf9 cells using biotinyl-DLDLEMLAPYIPMDDDFQL as substrate preincubated with compound for 30 mins measured after 2 hrs by time resolved fluorescence analysis
Inhibition of FLAG-tagged PHD2 expressed in baculovirus infected insect sf9 cells using biotinyl-DLDLEMLAPYIPMDDDFQL as substrate preincubated with compound for 30 mins measured after 2 hrs by time resolved fluorescence analysis
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[PMID: 22364528] |
Chemical Information
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CAS No. 1258877-17-6
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Molecular Weight 504.58
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Formula C30H28N6O2
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SMILES
O=C(N(C1=CC=C(C2=CC=CC=C2)C=C1)C(N3C4=NC=CC=N4)=O)C3(CC5)CCN5CC6=NC=CC=C6C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JPHM-2-167 Related Classifications
HY-170914 Related Classifications
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