Losmapimod (Standard)
Losmapimod (GSK-AHAB; GW856553X) (Standard) is the analytical standard of Losmapimod (HY-10402). This product is intended for research and analytical applications. Losmapimod (GSK-AHAB; GW856553X) is an orally active p38α/β MAPK inhibitor, with pKi values of 8.1 and 7.6 for p38α and p38β, respectively. Losmapimod reduces DUX4 expression, thus exerting efficacy in facioscapulohumeral muscular dystrophy. By inhibiting MAPK/NF-κB, Losmapimod reduces apoptosis of epileptiform hippocampal neurons, and exhibits anti-allodynia and anti-hyperalgesic activities. Losmapimod blocks the entry and fusion of Lassa fever virus (LASV). Losmapimod overcomes tyrosine kinase inhibitor resistance in non-small cell lung cancer (NSCLC). Losmapimod inhibits myocardial senescence and inflammation, and possesses cardioprotective activity against cardiotoxicity.
For research use only. We do not sell to patients.
- Purity : 98%
- CAS No.: 585543-15-3
- Formula: C22H26FN3O2
- Molecular Weight:383.46
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- Purity & Documentation
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Help & FAQs
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Product Information
Information
Application
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 585543-15-3
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Molecular Weight 383.46
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Formula C22H26FN3O2
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SMILES
CC1=C(C2=NC=C(C(NCC(C)(C)C)=O)C=C2)C=C(C(NC3CC3)=O)C=C1F
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Synonyms
GSK-AHAB (Standard); GW856553X (Standard); SB856553 (Standard)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Losmapimod (Standard) Related Classifications
HY-10402R Related Classifications
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Keywords
- Losmapimod (Standard)
- 585543-15-3
- GSK-AHAB (Standard)
- GW856553X (Standard)
- SB856553 (Standard)
- Reference Standards
- p38 MAPK
- NF-κB
- Apoptosis
- Arenavirus
- Nuclear factor-κB
- Nuclear factor-kappaB
- p38α/β MAPK
- spinal cord microglial
- p21Cip1
- LASV
- hippocampal neuron
- HEK293T cells
- mitofusin2
- Vero E6 cells
- DUX4
- dorsal root ganglia
- Inhibitor
- inhibitor
- inhibit