MitoCur-1
Based on 1 publication(s) in Google Scholar
MitoCur-1, a curcumin analogue, is an inhibitor of mitochondrial antioxidative thioredoxin reductase 2 (TrxR2). MitoCur-1 has electrophilic and mitochondrial-targeting properties. MitoCur-1 induces reactive oxygen species (ROS) generation, exerts specifically antitumor efficacy.
For research use only. We do not sell to patients.
- Purity: ≥95.0%
- Formula: C65H64Cl2O6P2
- Molecular Weight:1074.05
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) MitoCur-1
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Biological Activity
Thioredoxin reductase 2 (TrxR2)[1]
MitoCur-1 exhibits selective cytotoxicity against HepG2 and L02 cells with IC50s of 1.4 μM and 9.1 μM, respectively[1].
MitoCur-1 (10 μM; 12 h) generates ROS and depletes GSH selectively in HepG2 cells over L02 cells[1].
MitoCur-1 (10 μM; 24 h) arrests cell cycle at G0/G1 phase, inhibits cyclin protein expression[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HepG2 cells
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Concentration:2.5 μM, 5 μM, and 10 μM
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Incubation Time:24 h, 36 h, and 48 h
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Result:Decreased the protein level of CDK2 and CDK4, Cyclin E1/D1/A2.
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Cell Line:HepG2 and L02 cells
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Concentration:10 μM
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Incubation Time:12 h
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Result:Showed selectivity on HepG2 cells over L02 cells to generates ROS. Promoted mitochondrial O2- production.
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Cell Line:HepG2 cells
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Concentration:1.25 μM, 2.5 μM, 5 μM, and 10 μM
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Incubation Time:48 h; pretreated with 400 μM DTT or not
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Result:Inhibited HepG2 cells viability. Showed significant reversion with DTT for 1 h pretreatment.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c nude mice bearing HepG2 tumor[1]
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Dosage:5 mg/kg, 15 mg/kg
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Administration:Intraperitoneal injection; every other day for 4 weeks
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Result:Decreased the tumor growth in vivo.
Chemical Information
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Appearance Solid
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Molecular Weight 1074.05
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Formula C65H64Cl2O6P2
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Color Light yellow to orange
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SMILES
O=C(C(C(/C=C/C1=CC=C(OCCC[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)C(OC)=C1)=O)(C)C)/C=C/C5=CC(OC)=C(OCCC[P+](C6=CC=CC=C6)(C7=CC=CC=C7)C8=CC=CC=C8)C=C5.[Cl-].[Cl-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Adv Sci (Weinh)
TrxR2 Lactylation Facilitates Mitochondrial Protection and Endothelial Ferroptosis Resistance in Diabetic Cardiomyopathy. [Abstract]2026 Apr;13(22):e21997. PMID: 41704008
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MitoCur-1 Related Classifications
HY-150228 Related Classifications
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