country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-181890

Copy Link Print Information

TRG-192

TRG-192 is a potent and selective glutaminase (GLS) inhibitor with an IC₅₀ of 68 nM. TRG-192 inhibits intracellular glutamate levels. TRG-192 is applicable to related research on non-small cell lung cancer.

For research use only. We do not sell to patients.

CAS No.: 3080792-24-8
Formula: C₂₄H₂₀F₆N₈O₂S₂
Molecular Weight:630.59

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

TRG-192 Chemical Structure

CAS No.: 3080792-24-8

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

IC₅₀: 68 nM (GLS)^[1]

In Vitro

TRG-192 potently inhibits glutaminase in cell-free in vitro biochemical assays, with an IC₅₀ of 68 nM^[1].
TRG-192 (0.01-1 μM; 72 h) potently inhibits the proliferation of glutamine-addicted NSCLC cell lines (A549, H460, H358), with IC₅₀ values of 0.068 μM, 0.038 μM and 0.035 μM respectively after 72 h of treatment^[1].
TRG-192 (0.3 μM; 24 h) significantly reduces intracellular glutamate levels in LDK378-resistant (LR) cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 3080792-24-8
Molecular Weight 630.59
Formula C₂₄H₂₀F₆N₈O₂S₂
SMILES

O=C(NCC1=NC=CC(C(F)(F)F)=C1)C2=NN=C(CCCCC3=NN=C(C(NCC4=NC=CC(C(F)(F)F)=C4)=O)S3)S2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Cyriac R, et al. Design, synthesis and biological evaluation of symmetric thiadiazole carboxamide derivative as glutaminase inhibitor. Bioorg Med Chem Lett. Published online February 21, 2026. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote