siRNAs

SPP1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for SPP1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

STAT3 Human Pre-designed siRNA Set A contains three designed siRNAs for STAT3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Plozasiran is an siRNA targeting APOC3 for the study of mixed hyperlipidemia.

LDHB Human Pre-designed siRNA Set A contains three designed siRNAs for LDHB gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TFRC Human Pre-designed siRNA Set A contains three designed siRNAs for TFRC gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IRF1 Human Pre-designed siRNA Set A contains three designed siRNAs for IRF1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HMOX1 Human Pre-designed siRNA Set A contains three designed siRNAs for HMOX1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

GSDMD Human Pre-designed siRNA Set A contains three designed siRNAs for GSDMD gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cemdisiran sodium (ALN-CC5 sodium) is an N-acetylgalactosamine-conjugated RNAi agent and also a complement component C5 inhibitor. Cemdisiran sodium targets C5 mRNA, cleaves C5 mRNA via the endogenous RNA interference pathway, and inhibits the production of C5 protein in the liver. Cemdisiran sodium exerts a dose-dependent inhibitory effect on total C5 concentrations in cynomolgus monkeys. When used in combination with Pozelimab (HY-P99786) in cynomolgus monkeys, Cemdisiran sodium achieves a more sustained and complete inhibitory effect on complement activity. Cemdisiran sodium can be used in the research of paroxysmal nocturnal hemoglobinuria and other complement-mediated diseases.

CD274 Human Pre-designed siRNA Set A contains three designed siRNAs for CD274 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ANXA1 Human Pre-designed siRNA Set A contains three designed siRNAs for ANXA1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cy3-siRNA Negative Control is Cy3-labeled SiRNA Negative Control (HY-150150). Cy3-siRNA Negative Control can be used for easy visualization and assessment of transfection efficiency.

G3BP1 Human Pre-designed siRNA Set A contains three designed siRNAs for G3BP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Fazirsiran sodium is a second-generation RNAi agent. Fazirsiran sodium consistes of a cholesterol-conjugated RNAi trigger (chol-RNAi) to selectively degrade Alpha1-antitrypsin (AAT) mRNA by RNAi and a melittin-derived peptide conjugated to N-acetylgalactosamine (NAG) formulated as the excipient EX1 to promote endosomal escape of the chol-RNAi in hepatocytes. Fazirsiran sodium can be used in the study of Alpha-1 Antitrypsin Deficiency (AATD) liver disease. AATD is caused by mutations in the alpha-1 antitrypsin (SERPINA1) gene.

STUB1 Human Pre-designed siRNA Set A contains three designed siRNAs for STUB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

STING1 Human Pre-designed siRNA Set A contains three designed siRNAs for STING1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TFEB Human Pre-designed siRNA Set A contains three designed siRNAs for TFEB gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SQSTM1 Human Pre-designed siRNA Set A contains three designed siRNAs for SQSTM1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

GSDME Human Pre-designed siRNA Set A contains three designed siRNAs for GSDME gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RUNX1 Human Pre-designed siRNA Set A contains three designed siRNAs for RUNX1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.