P-gp inhibitor 14
P-gp inhibitor 14 (Compound 8a) is a high affinity P-gp inhibitor. P-gp inhibitor 14 reverses P-gp-mediated multidrug resistance (EC50=48.74 nM). P-gp inhibitor 14 has a weak inhibitory effect on CYP3A4 activity.
For research use only. We do not sell to patients.
- CAS No.: 2892571-47-8
- Formula: C37H38N2O8
- Molecular Weight:638.71
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| K562/A02 | EC50 |
48.74 nM
Compound: 8a
|
Reversal of adriamycin resistance in human K562/A02 cells incubated for 48 hrs
Reversal of adriamycin resistance in human K562/A02 cells incubated for 48 hrs
|
[PMID: 36708676] |
| K562/A02 | IC50 |
0.026 μM
Compound: 8a
|
Reversal of multi-drug resistance in human K562/A02 cells assessed as ADR IC50
Reversal of multi-drug resistance in human K562/A02 cells assessed as ADR IC50
|
[PMID: 36708676] |
| K562/A02 | IC50 |
0.08 μM
Compound: 8a
|
Reversal of multi-drug resistance in human K562/A02 cells assessed as ADR IC50 at 0.4 uM
Reversal of multi-drug resistance in human K562/A02 cells assessed as ADR IC50 at 0.4 uM
|
[PMID: 36708676] |
| K562/A02 | IC50 |
95.4 μM
Compound: 8a
|
Cytotoxicity against human K562/A02 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
Cytotoxicity against human K562/A02 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
|
[PMID: 36708676] |
Chemical Information
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CAS No. 2892571-47-8
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Molecular Weight 638.71
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Formula C37H38N2O8
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SMILES
COC1=CC2=C(CN(CC2)CCC3=CC=C(C=C3)N4CC5=CC(OC)=C6OCOC6=C5C7=C(C4)C=C(C8=C7OCO8)OC)C=C1OC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)