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Cat. No.: HY-189243

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P2Y2R antagonist-2

P2Y2R antagonist-2 is an antagonist of the P2Y2 receptor (P2Y2R), with a pK_i value of 6.53 for human P2Y2R. P2Y2R antagonist-2 blocks UTPγS (HY-137603)-induced calcium mobilization, binds to the orthosteric site of P2Y2R to displace fluorescent antagonist ligands, and forms unique binding interactions. P2Y2R antagonist-2 has no structural alerts, exhibiting low lipophilicity and high lipophilic efficiency. P2Y2R antagonist-2 can be used in studies related to astrocytoma and inflammation.

For research use only. We do not sell to patients.

Formula: C₂₆H₂₄ClN₇O₅S
Molecular Weight:582.03

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

P2Y2R antagonist-2 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

^[1]

P2Y2 Receptor

6.53 (pKi)

All P2Y Receptor Isoforms :

In Vitro

P2Y2R antagonist-2 (compound 26a) (0.1 nM-100 μM; 1 h) exhibits potent binding to P2Y2R in NLuc/P2Y2R 1321N1 membrane preparations, with a pK_i value of 6.53^[1].
P2Y2R antagonist-2 (0.1 nM-100 μM; 1 h) exhibits stable high affinity for P2Y2R in intact live NLuc/P2Y2 1321N1 cells, with a pK_i value of 6.55^[1].
P2Y2R antagonist-2 (10 μM; 45 min) effectively inhibits UTPγS-induced intracellular calcium mobilization in 1321N1 cells expressing P2Y2R, with a pA₂ value of 5.56^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 582.03
Formula C₂₆H₂₄ClN₇O₅S
SMILES

O=C(O)C([H])N(C1=NC=CC(N(C(N2)=O)C=C(C3C4=CC=C(Cl)C=C4C=CC5=C3N=C(NCCOC)S5)C2=O)=N1)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Puthanveedu M, et al. Discovery of uracil-based antagonists and fluorescent ligands of the P2Y receptor. European journal of medicinal chemistry. 2026 Nov 15;318:119216.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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