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Cat. No.: HY-190673

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PAR4 antagonist 10

PAR4 antagonist 10 is a PAR4 antagonist (IC₅₀ = 1.8 nM) that antagonizes PAR4 signaling. PAR4 antagonist 10 can be used for research on thrombosis.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 2173202-87-2
Formule: C₂₆H₁₉ClFN₅O₄S
Masse moléculaire:551.98

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (286 KB)

PAR4 antagonist 10 Chemical Structure

CAS No.: 2173202-87-2

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Quantité

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

PAR4 antagonist 10 is a PAR4 antagonist (IC₅₀ = 1.8 nM) that antagonizes PAR4 signaling. PAR4 antagonist 10 can be used for research on thrombosis^[1].

IC₅₀ & Target

^[1]

PAR4

1.8 nM (IC₅₀)

Voir tous les produits spécifiques à Isoform Protease Activated Receptor (PAR) :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC50	1.8 nM	Antagonism of PAR4 in HEK293-PAR4 cells assessed by FLIPR calcium mobilization assay using a synthetic peptide agonist. Antagonism of PAR4 in HEK293-PAR4 cells assessed by FLIPR calcium mobilization assay using a synthetic peptide agonist.	42858890

In Vitro

PAR4 antagonist 10 (compound 27) antagonizes PAR4 in HEK293-PAR4 cells with an IC₅₀ of 1.8 nM in the FLIPR calcium mobilization assay^[1].
PAR4 antagonist 10 antagonizes PAR in Human γ-Thrombin (HY-114164B)-stimulated platelet-rich plasma with an IC₅₀ of 3.7 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	C_max
Rat^[1]	2 mg/kg	p.o.	2.2 μM

In Vivo

PAR4 antagonist 10 (compound 27) (2 mg/kg; p.o.; single dose) has an AUC_T of 23 μMh in rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2173202-87-2
Masse moléculaire 551.98
Formule C₂₆H₁₉ClFN₅O₄S
SMILES

COC1=CC2=CC(Cl)=CC(C3=NC(C=C(F)C4=C5C[C@H](COC(NC6=CN=C(C)N=C6)=O)O4)=C5S3)=C2N=C1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (286 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Richter JM, et al. Benzothiazoloquinolines as protease-activated receptor 4 (PAR4) antagonists with excellent rat pharmacokinetic properties. Bioorganic & medicinal chemistry letters. 2026 Oct 10;143:130795. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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