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Cat. No.: HY-149661

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PDE5-IN-11

PDE5-IN-11 is a potent inhibitor of PDE5 with an IC₅₀ of 40 nM. PDE5-IN-11 also inhibits PDE4 and PDE6 with IC₅₀s of 1.78 and 0.09 μM, respectively.

For research use only. We do not sell to patients.

Formula: C₂₀H₂₈N₆O₄
Molecular Weight:416.47

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

PDE5-IN-11 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

PDE5-IN-11 is a potent inhibitor of PDE5 with an IC₅₀ of 40 nM. PDE5-IN-11 also inhibits PDE4 and PDE6 with IC₅₀s of 1.78 and 0.09 μM, respectively^[1].

All Phosphodiesterase (PDE) Isoforms :

Chemical Information

Molecular Weight 416.47
Formula C₂₀H₂₈N₆O₄
SMILES

COC1=CC=C(CNC2=C3C(N(C(C)C)C(N3)=O)=NC(N(CCO)CCO)=N2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jiayuan Liu, et al. Drug repurposing and structure-based discovery of new PDE4 and PDE5 inhibitors, European Journal of Medicinal Chemistry (2023).

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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PDE5-IN-11

All Phosphodiesterase (PDE) Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PDE5-IN-11 Related Classifications

HY-149661 Related Classifications