PDGFR Tyrosine kinase-IN-1

Name: PDGFR Tyrosine kinase-IN-1
Brand: MedChemExpress
SKU: HY-112412
Rating: 4.5 (0 reviews)

製品番号: HY-112412 純度: 99.07%: Data Sheet SDS COA 取扱説明書
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PDGFR Tyrosine kinase-IN-1, a multikinase inhibitor, inhibits PDGFR, EGFR, FGFR, PKA, and PKC, respectively. PDGFR Tyrosine kinase-IN-1 can be used for the research of amyotrophic lateral sclerosis.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

PDGFR Tyrosine kinase-IN-1 構造式

CAS 番号 : 205254-94-0

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 53	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 53	在庫あり	Estimated Time of Arrival: December 31
Solid
5 mg	$50	在庫あり	Estimated Time of Arrival: December 31
10 mg	$80	在庫あり	Estimated Time of Arrival: December 31
25 mg	$160	在庫あり	Estimated Time of Arrival: December 31
50 mg	$260	在庫あり	Estimated Time of Arrival: December 31
100 mg	$415	在庫あり	Estimated Time of Arrival: December 31
200 mg		お問い合わせ
500 mg		お問い合わせ

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カスタマーレビュー

Based on 0 publication(s) in Google Scholar

PDGFR アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

PDGFR PDGFRβ PDGFRα

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

PDGFR Tyrosine kinase-IN-1, a multikinase inhibitor, inhibits PDGFR, EGFR, FGFR, PKA, and PKC, respectively. PDGFR Tyrosine kinase-IN-1 can be used for the research of amyotrophic lateral sclerosis^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	> 0.08 μM Compound: 1a	Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells	[PMID: 12941321]
PASMC	IC₅₀	0.25 μM Compound: 21	Inhibition of PDGF-BB-induced proliferation of porcine aorta smooth muscle cells Inhibition of PDGF-BB-induced proliferation of porcine aorta smooth muscle cells	[PMID: 12086491]

分子量

485.53

分子式

C₂₇H₂₇N₅O₄

CAS 番号

205254-94-0

Appearance

Solid

Color

White to off-white

SMILES

O=C(N1CCN(C2=C3C=C(OC)C(OC)=CC3=NC=N2)CC1)NC4=CC=C(OC5=CC=CC=C5)C=C4

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (205.96 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0596 mL	10.2980 mL	20.5961 mL
5 mM	0.4119 mL	2.0596 mL	4.1192 mL
10 mM	0.2060 mL	1.0298 mL	2.0596 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1.67 mg/mL (3.44 mM); Clear solution

This protocol yields a clear solution of ≥ 1.67 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (16.7 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 1.67 mg/mL (3.44 mM); Clear solution

This protocol yields a clear solution of ≥ 1.67 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (16.7 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 1.67 mg/mL (3.44 mM); Clear solution

This protocol yields a clear solution of ≥ 1.67 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (16.7 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

純度とドキュメンテーション

純度: 99.07%

Select Batch:

データシート (271 KB) SDS (252 KB)

COA (250 KB) HNMR (276 KB) LCMS (102 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Young-Min Lee. Compositions and methods for zika virus characterization and vaccine development. WO2019204654A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.0596 mL	10.2980 mL	20.5960 mL	51.4901 mL
	5 mM	0.4119 mL	2.0596 mL	4.1192 mL	10.2980 mL
	10 mM	0.2060 mL	1.0298 mL	2.0596 mL	5.1490 mL
	15 mM	0.1373 mL	0.6865 mL	1.3731 mL	3.4327 mL
	20 mM	0.1030 mL	0.5149 mL	1.0298 mL	2.5745 mL
	25 mM	0.0824 mL	0.4119 mL	0.8238 mL	2.0596 mL
	30 mM	0.0687 mL	0.3433 mL	0.6865 mL	1.7163 mL
	40 mM	0.0515 mL	0.2575 mL	0.5149 mL	1.2873 mL
	50 mM	0.0412 mL	0.2060 mL	0.4119 mL	1.0298 mL
	60 mM	0.0343 mL	0.1716 mL	0.3433 mL	0.8582 mL
	80 mM	0.0257 mL	0.1287 mL	0.2575 mL	0.6436 mL
	100 mM	0.0206 mL	0.1030 mL	0.2060 mL	0.5149 mL