Pertuzumab (anti-HER2)
Based on 10 publication(s) in Google Scholar
Pertuzumab (anti-HER2), a humanized monoclonal antibody, is a HER2 dimerization inhibitor for the treatment of metastatic HER2-positive breast cancer.
For research use only. We do not sell to patients.
- Purity: 99.10%
- CAS No.: 380610-27-5
- Molecular Weight:144 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications Citing Use of MedChemExpress (MCE) Pertuzumab (anti-HER2)
More- Nat Nanotechnol. 2025 Feb;20(2):296-302. [Abstract]
- J Invest Dermatol. 2023 May;143(5):832-841.e4. [Abstract]
- Anal Chim Acta. 2021 Apr 15:1154:338306. [Abstract]
- Commun Biol. 2024 May 28;7(1):652. [Abstract]
- Int J Cancer. 2024 Jul 15;155(2):324-338. [Abstract]
- Sci Rep. 2024 Feb 14;14(1):3771. [Abstract]
- EJNMMI Radiopharm Chem. 2025 Apr 4;10(1):16. [Abstract]
- Breast Cancer Res Treat. 2026 Mar 13;216(3):25. [Abstract]
- bioRxiv. 2026 Jun 19.
- SSRN. 2025 Jul 25.
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In Vivo Imaging
All EGFR Isoforms
More
Biological Activity
Human IgG1 kappa
Human
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HER2 |
Trastuzumab and Pertuzumab are highly synergistic inhibitors of BT474 breast cancer cell survival. The combination of trastuzumab and Pertuzumab mediates a loss of up to 60% of cells at doses in which individual drugs do not alter cell survival. The combination of trastuzumab and Pertuzumab reduces the percentage of proliferating (S-phase) cells by more than 2-fold. A combination of trastuzumab and Pertuzumab inhibits cell proliferation and survival to a greater degree than does either agent alone[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Human IgG1 kappa
ELISA, FACS, Functional assay
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Immobilized Human Her2/ERBB2 Protein (ECD, His Tag) can bind Pertuzumab (anti-HER2). The EC50 for this effect is 12.73 μg/mL. -
Pertuzumab has a significant ADCC effect on SK-BR-3 cells in a dose-dependent manner.The EC50 for this effect is 61.54 and 74.56 ng/mL.
Chemical Information
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CAS No. 380610-27-5
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Appearance Liquid
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Molecular Weight 144 kDa
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Color Colorless to light yellow
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SMILES
[Pertuzumab (anti-HER2)]
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (10)
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Journal Impact Factor
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Most Recent
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Nat Nanotechnol
2025 Feb;20(2):296-302. PMID: 39468359 -
J Invest Dermatol
Cathelicidin Antimicrobial Peptide LL37 Induces TLR8 and Amplifies IL-36γ and IL-17C in Human Keratinocytes. [Abstract]2023 May;143(5):832-841.e4. PMID: 36496195 -
Anal Chim Acta
Calibration for quantitative Fc-glycosylation analysis of therapeutic IgG1-type monoclonal antibodies by using glycopeptide standards. [Abstract]2021 Apr 15:1154:338306. PMID: 33736796 -
Commun Biol
Epitope binning for multiple antibodies simultaneously using mammalian cell display and DNA sequencing. [Abstract]2024 May 28;7(1):652. PMID: 38806676 -
Int J Cancer
Establishment of patient-derived organoids for guiding personalized therapies in breast cancer patients. [Abstract]2024 Jul 15;155(2):324-338. PMID: 38533706 -
Sci Rep
Dual anti-HER2/EGFR inhibition synergistically increases therapeutic effects and alters tumor oxygenation in HNSCC. [Abstract]2024 Feb 14;14(1):3771. PMID: 38355949
Pertuzumab (anti-HER2) purchased from MedChemExpress. Usage Cited in: Sci Rep. 2024 Feb 14;14(1):3771. [Abstract]
In vivo probing of HER2 and EGFR in FADU tumors with immune-PET imaging. FADU tumors were injected and imaged with [89Zr]-pertuzumab PET imaging. Pertuzumab (10 mg/mL) was conjugated with 0.4 mg deferoxamine (DFO). DFO–pertuzumab was labeled with [⁸⁹Zr] at 6 µCi/µg, and approximately 66.8 ± 15 µCi [⁸⁹Zr]‑pertuzumab (n = 6) was injected intravenously. Approximately 10–12 µg of radiolabeled antibody was administered before imaging.
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EJNMMI Radiopharm Chem
2025 Apr 4;10(1):16. PMID: 40183827 -
Breast Cancer Res Treat
Molecular imaging of tucatinib-induced cellular and TME changes in preclinical models of HER2 + breast cancer. [Abstract]2026 Mar 13;216(3):25. PMID: 41824101 -
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Purity & Documentation
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Data Sheet (261 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Nahta R, et al. The HER-2-targeting antibodies trastuzumab and pertuzumab synergistically inhibit the survivalof breast cancer cells. Cancer Res. 2004 Apr 1;64(7):2343-6. [Content Brief]
[2]. Scheuer W, et al. Strongly enhanced antitumor activity of trastuzumab and pertuzumab combination treatment on HER2-positive human xenograft tumor models. Cancer Res. 2009 Dec 15;69(24):9330-6. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)