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Cat. No.: HY-W050026A

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Phenylacetylglutamine sodium

Name: Phenylacetylglutamine sodium
Brand: MedChemExpress
SKU: HY-W050026A
Availability: PreOrder

(Synonyms: NSC 203800 sodium; Phenylacetyl-L-glutamine sodium)

3 Cited Publications

Customer Review

Based on 3 publication(s) in Google Scholar

Phenylacetylglutamine (sodium) can be obtained from the hydrolysis of Antineoplaston A10. Phenylacetylglutamine (sodium) exhibits antineoplastic activity in breast carcinoma tissue culture. Phenylacetylglutamine (sodium) exerts low actue and chronic toxicity in mouse model. Phenylacetylglutamine (sodium) can be studied in research on breast cancer.

For research use only. We do not sell to patients.

CAS No.: 104771-87-1
Formula: C₁₃H₁₅N₂NaO₄
Molecular Weight:286.26

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Phenylacetylglutamine sodium Chemical Structure

CAS No.: 104771-87-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Publications (3)
Protocols (3)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

Microbial Metabolite

Human Endogenous Metabolite

All Endogenous Metabolite Isoforms :

Chemical Information

CAS No. 104771-87-1
Molecular Weight 286.26
Formula C₁₃H₁₅N₂NaO₄
SMILES

O=C(CC1=CC=CC=C1)N[C@H](C(O[Na])=O)CCC(N)=O
Synonyms

NSC 203800 sodium; Phenylacetyl-L-glutamine sodium
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (3)

All Cell Proliferation/Viability AssayFlow CytometryIn Vivo Efficacy StudyCell Migration/Invasion Assay

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Cell Metab

Interplay between gut microbial communities and metabolites modulates pan-cancer immunotherapy responses. [Abstract]

2025 Apr 1;37(4):806-823.e6. PMID: 39909032

Phenylacetylglutamine sodium purchased from MedChemExpress. Usage Cited in: Cell Metab. 2025 Apr 1;37(4):806-823.e6. [Abstract]

Phenylacetylglutamine (PAGln, 50 mg/kg/day; i.p.) attenuated the inhibitory effect of anti-PD-1 on tumor growth in C57BL/6 SPF mice.
Respir Res

Phenylacetylglutamine produced from injury lung alveolar epithelial cells promotes the function of BMSCs by regulating NONRATT006276.2/Mapt pathway. [Abstract]

2025 May 24;26(1):196. PMID: 40413470

Phenylacetylglutamine sodium purchased from MedChemExpress. Usage Cited in: Respir Res. 2025 May 24;26(1):196. [Abstract]

BMSCs were treated the metabolites (UA [180, 360, 720 µM], NMDA [5, 50, 100 µM], Phenylacetylglutamine [PAG, 0.32, 3.2, 7.2 µM]) for 48 h respectively, and cell viability was detected by MTT assay. The results showed that Phenylacetylglutamin (PAG, 0.32–7.2 µM; 48 h) was non-toxic to BMSCs.

Phenylacetylglutamine sodium purchased from MedChemExpress. Usage Cited in: Respir Res. 2025 May 24;26(1):196. [Abstract]

Phenylacetylglutamin (PAG, 3.6–7.2 µM; 24 h) significantly promoted the migration ability of BMSCs.

Phenylacetylglutamine sodium purchased from MedChemExpress. Usage Cited in: Respir Res. 2025 May 24;26(1):196. [Abstract]

Phenylacetylglutamin (7.2 µM; 24 h) significantly promoted the migration ability of BMSCs.
Biomolecules

PAGln, an Atrial Fibrillation-Linked Gut Microbial Metabolite, Acts as a Promoter of Atrial Myocyte Injury. [Abstract]

2022 Aug 15;12(8):1120. PMID: 36009014

Phenylacetylglutamine sodium purchased from MedChemExpress. Usage Cited in: Biomolecules. 2022 Aug 15;12(8):1120. [Abstract]

Phenylacetylglutamine (PAGln, 100 μM, 24 h) intervention significantly increased ROS generation (1.44 vs. 0.80 fold change; p = 0.011), and apoptosis (56.25 vs. 49.76 %, p = 0.002) in mouse HL-1 cells.

Protocols

All Animals and Diseases

Subchronic/Chronic Toxicity Study
A subchronic/chronic oral toxicity study detects systemic adverse effects caused by repeated administration of a test article, using mortality, clinical signs, body weight, food/water intake, ophthalmology, urinalysis, hematology, serum biochemistry, organ weights, gross necropsy, and histopathology as integrated readouts. The readout reflects dose-related physiological injury, target-organ pathology, reversibility after recovery, and derivation of NOAEL, LOAEL, or related point-of-departure values when the dataset supports them.
Breast Cancer Modeling
Breast cancer is a heterogeneous cancer, and it has been distinguished into four subtypes: luminal A, luminal B, HER2-positive and basal-like. Molecular mutations, epigenetic alterations, hormone exposure and immune microenvironment are related to the progression of breast cancer.
How to Choose the Right Model Animal
Choosing the right model animal is a validity-driven decision in which the species, strain, sex, age, genetic background, disease-induction method, outcome measures, and welfare burden must match the scientific question rather than laboratory tradition or convenience. A model should be selected by judging face validity, construct validity, and predictive validity: whether it resembles the human phenotype, whether it reproduces relevant mechanisms, and whether results are likely to predict human biology or treatment response. Animal studies often fail to translate because of species differences, weak disease resemblance, poor experimental design, inadequate reporting, publication bias, and underuse of randomization, blinding, and sample-size justification. Unresolved questions include how to rank competing models objectively, how much human-disease complexity must be reproduced for a given objective, and when non-animal systems such as organoids, ex vivo tissue, or computational models

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Burzynski SR, et al., Preclinical studies on antineoplaston AS2-1 and antineoplaston AS2-5. Drugs Exp Clin Res. 1986;12 Suppl 1:11-6. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

Phenylacetylglutamine sodium

3 Cited Publications

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Publications (3)
Protocols
Purity & Documentation
References

1/16
1/16

Phenylacetylglutamine sodium purchased from MedChemExpress. Usage Cited in: Cell Metab. 2025 Apr 1;37(4):806-823.e6. [Abstract]

Customer Validation
Phenylacetylglutamine (PAGln, 50 mg/kg/day; i.p.) attenuated the inhibitory effect of anti-PD-1 on tumor growth in C57BL/6 SPF mice.
1/16

Phenylacetylglutamine sodium purchased from MedChemExpress. Usage Cited in: Respir Res. 2025 May 24;26(1):196. [Abstract]

Customer Validation
BMSCs were treated the metabolites (UA [180, 360, 720 µM], NMDA [5, 50, 100 µM], Phenylacetylglutamine [PAG, 0.32, 3.2, 7.2 µM]) for 48 h respectively, and cell viability was detected by MTT assay. The results showed that Phenylacetylglutamin (PAG, 0.32–7.2 µM; 48 h) was non-toxic to BMSCs.
1/16

Phenylacetylglutamine sodium purchased from MedChemExpress. Usage Cited in: Respir Res. 2025 May 24;26(1):196. [Abstract]

Customer Validation
Phenylacetylglutamin (PAG, 3.6–7.2 µM; 24 h) significantly promoted the migration ability of BMSCs.
1/16

Phenylacetylglutamine sodium purchased from MedChemExpress. Usage Cited in: Respir Res. 2025 May 24;26(1):196. [Abstract]

Customer Validation
Phenylacetylglutamin (7.2 µM; 24 h) significantly promoted the migration ability of BMSCs.
1/16

Phenylacetylglutamine sodium purchased from MedChemExpress. Usage Cited in: Biomolecules. 2022 Aug 15;12(8):1120. [Abstract]

Customer Validation
Phenylacetylglutamine (PAGln, 100 μM, 24 h) intervention significantly increased ROS generation (1.44 vs. 0.80 fold change; p = 0.011), and apoptosis (56.25 vs. 49.76 %, p = 0.002) in mouse HL-1 cells.

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Phenylacetylglutamine sodium

Publications Citing Use of MedChemExpress (MCE) Phenylacetylglutamine sodium

All Endogenous Metabolite Isoforms