Poly-L-γ-glutamic acid sodium

Cat. No.: HY-149449: Data Sheet
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Poly-L-γ-glutamic acid sodium is a macromolecular polymer formed by the linkage of glutamic acid residues via peptide bonds between γ-amino and carboxyl groups. Poly-L-γ-glutamic acid sodium plays an important role as a carrier material in compound delivery systems. Poly-L-γ-glutamic acid sodium can deliver Paclitaxel (HY-B0015) to colon cancer cells, reduce cell viability and inhibit the growth of colon cancer spheroids. Poly-L-γ-glutamic acid sodium can be used as a carrier material and in studies related to colon cancer in mice.

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Poly-L-γ-glutamic acid sodium Chemical Structure

CAS No. : 208106-41-6

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
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Description	Poly-L-γ-glutamic acid sodium is a macromolecular polymer formed by the linkage of glutamic acid residues via peptide bonds between γ-amino and carboxyl groups. Poly-L-γ-glutamic acid sodium plays an important role as a carrier material in compound delivery systems. Poly-L-γ-glutamic acid sodium can deliver Paclitaxel (HY-B0015) to colon cancer cells, reduce cell viability and inhibit the growth of colon cancer spheroids. Poly-L-γ-glutamic acid sodium can be used as a carrier material and in studies related to colon cancer in mice^[1]^[2].
In Vitro	Poly-L-γ-glutamic acid (sodium) (24 h) forms a complex with PTX that inhibits Colon-26 cell viability with an IC₅₀ of 2.2 nM after 24 h incubation^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Poly-L-γ-glutamic acid sodium Related Antibodies
Molecular Weight	750000 (minimum)
CAS No.	208106-41-6
Appearance	Solid
Color	White to off-white
SMILES	[Poly-L-g-glutamic acid (sodium)]
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	-20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Purity & Documentation	Select Batch: Data Sheet (265 KB) SDS (252 KB) COA (242 KB) Handling Instructions (2659 KB)
References	[1]. Riku Kawasaki, et al. Water solubilization of paclitaxel using polypeptides for cancer therapy. Mater. Adv., 2022, 3, 467-473 [2]. Jaimes-Aguirre L, et al. Biodegradable poly(D,L-lactide-co-glycolide)/poly(L-γ-glutamic acid) nanoparticles conjugated to folic acid for targeted delivery of doxorubicin. Mater Sci Eng C Mater Biol Appl. 2017 Jul 1;76:743-751. [Content Brief]