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Cat. No.: HY-P10327

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PP18

PP18 is a novel OXM-based dual GLP-1 and glucagon receptor agonist with EC₅₀ values of 0.487 nM target hGLP-1R and 0.188 nM target hGcgR.

For research use only. We do not sell to patients.

Formula: C₂₆₉H₄₂₆N₇₄O₈₈S₂
Molecular Weight:6168.83

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PP18 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

PP18 is a novel OXM-based dual GLP-1 and glucagon receptor agonist with EC₅₀ values of 0.487 nM target hGLP-1R and 0.188 nM target hGcgR^[1].

Chemical Information

Molecular Weight 6168.83
Formula C₂₆₉H₄₂₆N₇₄O₈₈S₂
Sequence

Ala-Cys-Ala-Glu-Leu-Val-Asp-Asn-Ala-Val-Ala-Ile-Gly-Gly-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys(AEEA-AEEA-γGlu-C18 diacid)-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-Ala-Arg-Asn-Arg-Asn-Asn-Ile-Ala
Sequence Shortening

ACAELVDNAVAIGGQGTFTSDYS-K(AEEA-AEEA-γGlu-C18 diacid)-YLDSRRAQDFVQWLMNTARNRNNIA
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (258 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lei Zhao, et al. Design, screening and biological evaluation of novel fatty acid chain-modified oxyntomodulin-based derivatives with prolonged glucose-lowering ability and potent anti-obesity effects. Org Biomol Chem. 2019, 17, 33. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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