preQ1 dihydrochloride
Based on 1 Customer Validation
preQ1 dihydrochloride is a modified, guanine-derived nucleobase and a precursor of Queuine (HY-N10574) biosynthesis. preQ1 dihydrochloride binds to the aptamer of PreQ1 riboswitch with high affinity.
For research use only. We do not sell to patients.
- Purity: 98.88%
- CAS No.: 86694-45-3
- Formula: C7H11Cl2N5O
- Molecular Weight:252.10
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
PreQ1 dihydrochloride is a modified, guanine-derived nucleobase that is incorporated into tRNAs at the wobble position, where it is further altered to produce queuosine. The PreQ1 riboswitch governs the expression of genes responsible for the biosynthesis of queuosine. The riboswitch regulates downstream gene expression in response to its cognate ligand PreQ1 dihydrochloride[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 86694-45-3
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Appearance Solid
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Molecular Weight 252.10
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Formula C7H11Cl2N5O
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Color White to light brown
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SMILES
O=C1C2=C(NC=C2CN)N=C(N)N1.[H]Cl.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 125 mg/mL (495.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 14.29 mg/mL (56.68 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 3.9667 mL | 19.8334 mL | 39.6668 mL | 99.1670 mL |
| 5 mM | 0.7933 mL | 3.9667 mL | 7.9334 mL | 19.8334 mL | |
| 10 mM | 0.3967 mL | 1.9833 mL | 3.9667 mL | 9.9167 mL | |
| 15 mM | 0.2644 mL | 1.3222 mL | 2.6445 mL | 6.6111 mL | |
| 20 mM | 0.1983 mL | 0.9917 mL | 1.9833 mL | 4.9583 mL | |
| 25 mM | 0.1587 mL | 0.7933 mL | 1.5867 mL | 3.9667 mL | |
| 30 mM | 0.1322 mL | 0.6611 mL | 1.3222 mL | 3.3056 mL | |
| 40 mM | 0.0992 mL | 0.4958 mL | 0.9917 mL | 2.4792 mL | |
| 50 mM | 0.0793 mL | 0.3967 mL | 0.7933 mL | 1.9833 mL | |
| DMSO | 60 mM | 0.0661 mL | 0.3306 mL | 0.6611 mL | 1.6528 mL |
| 80 mM | 0.0496 mL | 0.2479 mL | 0.4958 mL | 1.2396 mL | |
| 100 mM | 0.0397 mL | 0.1983 mL | 0.3967 mL | 0.9917 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
preQ1 dihydrochloride Related Classifications
HY-115642 Related Classifications
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