PROTAC BET Degrader-12
Based on 1 Customer Validation
PROTAC BET Degrader-12 (Compound 8b) is a PROTAC degrader for bromodomain and extra-terminal domain (BET)-containing proteins, which degrades the BRD3 and BRD4 in a DCAF11-dependent manner. PROTAC BET Degrader-12 inhibits cell viability of KBM7 with a DC50 of 305.2 nM
(Pink: BET ligand (HY-13030); Blue: DCAF11 ligand (HY-159076); Black: linker (HY-159077)).
For research use only. We do not sell to patients.
- Purity: 98.10%
- CAS No.: 3068070-16-3
- Formula: C48H47ClN8O4S
- Molecular Weight:867.46
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-L001
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HY-L024
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HY-L025
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HY-L079
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MCE Bioactive Compound Library
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High-Throughput Bioactive Compound Library
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All PROTACs Isoforms
More
Biological Activity
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BRD4 |
BRD3 |
Chemical Information
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CAS No. 3068070-16-3
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Appearance Solid
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Molecular Weight 867.46
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Formula C48H47ClN8O4S
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Color White to off-white
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SMILES
CC1=NN=C2[C@@H](N=C(C3=C(N12)SC(C)=C3C)C4=CC=C(C=C4)Cl)CC(NCCCCCCNC(COC5=CC=C(C=C5)CNC(/C(C#N)=C/C6=CC=C7C=CC=CC7=C6)=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 100 mg/mL (115.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (268 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.1528 mL | 5.7640 mL | 11.5279 mL | 28.8198 mL |
| 5 mM | 0.2306 mL | 1.1528 mL | 2.3056 mL | 5.7640 mL | |
| 10 mM | 0.1153 mL | 0.5764 mL | 1.1528 mL | 2.8820 mL | |
| 15 mM | 0.0769 mL | 0.3843 mL | 0.7685 mL | 1.9213 mL | |
| 20 mM | 0.0576 mL | 0.2882 mL | 0.5764 mL | 1.4410 mL | |
| 25 mM | 0.0461 mL | 0.2306 mL | 0.4611 mL | 1.1528 mL | |
| 30 mM | 0.0384 mL | 0.1921 mL | 0.3843 mL | 0.9607 mL | |
| 40 mM | 0.0288 mL | 0.1441 mL | 0.2882 mL | 0.7205 mL | |
| 50 mM | 0.0231 mL | 0.1153 mL | 0.2306 mL | 0.5764 mL | |
| 60 mM | 0.0192 mL | 0.0961 mL | 0.1921 mL | 0.4803 mL | |
| 80 mM | 0.0144 mL | 0.0720 mL | 0.1441 mL | 0.3602 mL | |
| 100 mM | 0.0115 mL | 0.0576 mL | 0.1153 mL | 0.2882 mL |
PROTAC BET Degrader-12 Related Classifications
HY-158764 Related Classifications
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