3068070-16-3
3068070-16-3
Chemical Structure
PROTAC BET Degrader-12
- CAS 番号: 3068070-16-3
- Formula:C48H47ClN8O4S
- Molecular Weight:867.46
InChIKey: SMTIDKSLOGSVOF-QINIHQOHSA-N
SMILES: CC1=NN=C2[C@@H](N=C(C3=C(N12)SC(C)=C3C)C4=CC=C(C=C4)Cl)CC(NCCCCCCNC(COC5=CC=C(C=C5)CNC(/C(C#N)=C/C6=CC=C7C=CC=CC7=C6)=O)=O)=O
Biological Activity: PROTAC BET Degrader-12 (Compound 8b) is a PROTAC degrader for bromodomain and extra-terminal domain (BET)-containing proteins, which degrades the BRD3 and BRD4 in a DCAF11-dependent manner. PROTAC BET Degrader-12 inhibits cell viability of KBM7 with a DC50 of 305.2 nM[1]
| 製品番号 | 製品名 | 純度 | 製品説明 | Pricing | |||||||||||||||||||
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PROTAC BET Degrader-12 | 98.10% | PROTAC BET Degrader-12 (Compound 8b) is a PROTAC degrader for bromodomain and extra-terminal domain (BET)-containing proteins, which degrades the BRD3 and BRD4 in a DCAF11-dependent manner. PROTAC BET Degrader-12 inhibits cell viability of KBM7 with a DC50 of 305.2 nM | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.74
HY-183302Anticancer agent 317 -
Similarity Score 0.72
HY-145125SJ995973 -
Similarity Score 0.71
HY-156774CCW 28-3 -
Similarity Score 0.69
HY-184952Anticancer agent 343 -
Similarity Score 0.68
HY-130256β-NF-JQ1 -
Similarity Score 0.67
HY-125232MS645 -
Similarity Score 0.67
HY-112588dBET6 -
Similarity Score 0.66
HY-129917KB02-JQ1 -
Similarity Score 0.65
HY-101838RdBET1 (Standard) -
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