PROTAC HPK1 Degrader-8
PROTAC HPK1 Degrader-8 is a HPK1 PROTAC degrader with a DC50 of 1-10 nM. PROTAC HPK1 Degrader-8 promotes HPK1 ubiquitination and degradation. PROTAC HPK1 Degrader-8 induces IL-2 production, with an EC50 of 3 nM. PROTAC HPK1 Degrader-8 can be used in research related to hematologic malignancies and solid tumors.
(Pink: HPK1 Target protein ligand; Blue: Cereblon ligand (HY-W115490); Black: linker).
For research use only. We do not sell to patients.
- CAS No.: 3120899-50-2
- Formula: C39H40ClN9O3
- Molecular Weight:718.25
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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HPK1 1-10 nM (DC50) |
IL-2 3 nM (EC50) |
Cereblon |
PROTAC HPK1 Degrader-8 (Compound 1) degrades HPK1 protein in peripheral blood mononuclear cells, with a DC50 of 1-10 nM and a Dmax of over 90%[1].
PROTAC HPK1 Degrader-8 (Compound 1) induces IL-2 production in hPBMC with an EC50 of 3 nM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3120899-50-2
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Molecular Weight 718.25
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Formula C39H40ClN9O3
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SMILES
O=C(NC(CC1)=O)N1C2=C(Cl)C=CC(C(N3CCC(CC4CCN(C5=NC=C(C6=NC(C(C7=CN=C(C)C=C7)=CN8)=C8N=C6)C=C5)CC4)CC3)=O)=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PROTAC HPK1 Degrader-8 Related Classifications
HY-184230 Related Classifications
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