3120899-50-2
3120899-50-2
Chemical Structure
PROTAC HPK1 Degrader-8
- CAS No.: 3120899-50-2
- Formula:C39H40ClN9O3
- Molecular Weight:718.25
InChIKey: CMRDVMNMXODINS-UHFFFAOYSA-N
SMILES: O=C(NC(CC1)=O)N1C2=C(Cl)C=CC(C(N3CCC(CC4CCN(C5=NC=C(C6=NC(C(C7=CN=C(C)C=C7)=CN8)=C8N=C6)C=C5)CC4)CC3)=O)=C2
Biological Activity: PROTAC HPK1 Degrader-8 is a HPK1 PROTAC degrader with a DC50 of 1-10 nM. PROTAC HPK1 Degrader-8 promotes HPK1 ubiquitination and degradation. PROTAC HPK1 Degrader-8 induces IL-2 production, with an EC50 of 3 nM. PROTAC HPK1 Degrader-8 can be used in research related to hematologic malignancies and solid tumors[1][2].
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PROTAC HPK1 Degrader-8 | PROTAC HPK1 Degrader-8 is a HPK1 PROTAC degrader with a DC50 of 1-10 nM. PROTAC HPK1 Degrader-8 promotes HPK1 ubiquitination and degradation. PROTAC HPK1 Degrader-8 induces IL-2 production, with an EC50 of 3 nM. PROTAC HPK1 Degrader-8 can be used in research related to hematologic malignancies and solid tumors. | |||||||||||||||||||||
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References
- [1]. Renner AC, et al. Degrading Immune Checkpoints and Coordinating Oncogenic Signaling: Emerging Strategies in Cancer Therapy. ACS Med Chem Lett. 2026 May 26;17(6):1243-1245. . [Content Brief]
- [2]. Lichao FANG, et al. Bifunctional kinase modulators, compositions comprising the same, and methods of using the same. WO2026055926A1. WIPO (PCT). 2024-09-13.
Keywords
